Peciña Susana, Smith Kyle S, Berridge Kent C
Department of Psychology, University of Michigan, Ann Arbor, MI 48109-1109, USA.
Neuroscientist. 2006 Dec;12(6):500-11. doi: 10.1177/1073858406293154.
Hedonic "liking" for sensory pleasures is an important aspect of reward, and excessive 'liking' of particular rewards might contribute to excessive consumption and to disorders such as obesity. The present review aims to summarize recent advances in the identification of brain substrates for food 'liking' with a focus on opioid hot spots in the nucleus accumbens and ventral pallidum. Drug microinjection studies have shown that opioids in both areas amplify the 'liking' of sweet taste rewards. Modern neuroscience tools such as Fos plume mapping have further identified hedonic hot spots within the accumbens and pallidum, where opioids are especially tuned to magnify 'liking' of food rewards. Hedonic hot spots in different brain structures may interact with each other within the larger functional circuitry that interconnects them. Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in 'liking' for many rewards.
对感官愉悦的享乐性“喜好”是奖赏的一个重要方面，对特定奖赏的过度“喜好”可能导致过度消费以及肥胖等疾病。本综述旨在总结在确定食物“喜好”的脑基质方面的最新进展，重点关注伏隔核和腹侧苍白球中的阿片类热点。药物微量注射研究表明，这两个区域的阿片类物质都会增强对甜味奖赏的“喜好”。诸如Fos羽流图谱等现代神经科学工具进一步确定了伏隔核和苍白球内的享乐热点，其中阿片类物质特别适合放大对食物奖赏的“喜好”。不同脑结构中的享乐热点可能在将它们相互连接的更大功能回路中相互作用。更好地理解脑享乐热点如何增加自然感官愉悦的积极情感影响，将有助于刻画可能参与对多种奖赏“喜好”的神经机制。
