Toxicological effects of Carica papaya seed extract on spermatozoa of mice.

Investigations were carried out on epididymal spermatozoa of male mice to study the effects of high dosages (100, 200 and 300 mg kg(-1) bwt) of aqueous Carica papaya seed extract. The results revealed a significant dosedependent suppression of cauda epididymal sperm motility coinciding with a decrease in sperm count and viability. When tested 45 days after the withdrawal of treatment, complete normalcy was restored, proving that the induced effects were transient.