Annabi Borhane, Currie Jean-Christophe, Moghrabi Albert, Béliveau Richard
Laboratoire d'Oncologie Moléculaire, Département de Chimie, Centre BIOMED, Université du Québec à Montréal, Montreal, Quebec, Canada.
Leuk Res. 2007 Sep;31(9):1277-84. doi: 10.1016/j.leukres.2006.10.001. Epub 2006 Nov 1.
Matrix metalloproteinase (MMP)-9 expression is linked with myeloid cell differentiation, as well as inflammation and angiogenesis processes related to cancer progression. MMP-9 secretion and macrophage-like HL-60 myeloid leukemia cells differentiation were triggered by the tumor-promoting agent PMA. The chemopreventive effects of green tea catechins epigallocatechin-gallate, catechin-gallate, and epicatechin-gallate, but not those catechins that lack a 3'-galloyl group, inhibited in a time- and dose-dependent manner MMP-9 secretion. The gene and protein expression of MMP-9 and of the mRNA stabilizing factor HuR were also inhibited, while that of the 67 kDa laminin receptor remained unaffected. Specific catechins may help optimize current chemotherapeutic treatment protocols for leukemia.
基质金属蛋白酶（MMP）-9的表达与髓细胞分化以及与癌症进展相关的炎症和血管生成过程有关。促肿瘤剂佛波酯（PMA）可引发MMP-9的分泌以及巨噬细胞样HL-60髓系白血病细胞的分化。绿茶儿茶素表没食子儿茶素没食子酸酯、儿茶素没食子酸酯和表儿茶素没食子酸酯具有化学预防作用，但缺乏3'-没食子酰基的儿茶素则没有，它们能以时间和剂量依赖性方式抑制MMP-9的分泌。MMP-9以及mRNA稳定因子HuR的基因和蛋白表达也受到抑制，而67 kDa层粘连蛋白受体的表达则不受影响。特定的儿茶素可能有助于优化当前白血病的化疗治疗方案。
