肝细胞生长因子是人类黑素细胞DNA合成和生长的有效刺激物。
Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth.
作者信息
Matsumoto K, Tajima H, Nakamura T
机构信息
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Apr 15;176(1):45-51. doi: 10.1016/0006-291x(91)90887-d.
Hepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors, while it was inhibited by transforming growth factor-beta 1. Melanocytes expressed a single class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 receptors/cell. Thus, HGF is a potent mitogen for normal human epidermal melanocytes.
肝细胞生长因子（HGF）是原代培养的成年大鼠肝细胞的一种强效有丝分裂原。HGF可刺激培养的正常人表皮黑素细胞的生长和DNA合成。10 ng/ml的HGF可使DNA合成产生4.0倍的最大刺激。这种刺激作用与酸性和碱性成纤维细胞生长因子均具有加和性，而被转化生长因子-β1抑制。黑素细胞表达一类单一的、对HGF具有特异性的高亲和力受体，解离常数为22 pM，每个细胞约有120个受体。因此，HGF是正常人表皮黑素细胞的一种强效有丝分裂原。
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