Cooke Jana R, Liu Lianqi, Natarajan Loki, He Feng, Marler Matthew, Loredo Jose S, Corey-Bloom Jody, Palmer Barton W, Greenfield Deborah, Ancoli-Israel Sonia
Department of Medicine, University of California, San Diego, Veterans Affairs San Diego Healthcare System, CA, USA.
Behav Sleep Med. 2006;4(4):219-27. doi: 10.1207/s15402010bsm0404_2.
Patients with Alzheimer's disease (AD) commonly have poor sleep and a high reported incidence of sleep-disordered breathing (SDB). This study examined how the presence of SDB affected sleep stages in AD patients. Sixty-six volunteers with mild - moderate AD underwent home polysomnography. Results showed that patients with SDB spent less of the night in REM sleep than those with no SDB, but there were no differences in other sleep stages. The findings suggest that the decreased amount of REM sleep may be due to the presence of AD and SDB. Treating these patients' SDB may increase their amount of REM sleep, which may result in improved daytime functioning. Controlled trials of SDB treatment in AD are needed to answer this question.
阿尔茨海默病（AD）患者通常睡眠质量差，且据报告睡眠呼吸障碍（SDB）的发病率很高。本研究调查了SDB的存在如何影响AD患者的睡眠阶段。66名轻度至中度AD志愿者接受了家庭多导睡眠图检查。结果显示，与无SDB的患者相比，有SDB的患者快速眼动睡眠（REM睡眠）时间较少，但在其他睡眠阶段没有差异。研究结果表明，REM睡眠时间减少可能是由于AD和SDB的存在。治疗这些患者睡眠呼吸障碍可能会增加他们的REM睡眠时间，这可能会改善他们的日间功能。需要对AD患者进行SDB治疗的对照试验来回答这个问题。
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