Rivlin-Etzion Michal, Marmor Odeya, Heimer Gali, Raz Aeyal, Nini Asaph, Bergman Hagai
Department of Physiology, The Interdisciplinary Center for Neural Computation, The Hebrew University-Hadassah Medical School, Jerusalem, Israel, 91120.
Curr Opin Neurobiol. 2006 Dec;16(6):629-37. doi: 10.1016/j.conb.2006.10.002. Epub 2006 Nov 3.
Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.
低频静止性震颤是帕金森病及其一些动物模型的主要体征之一。目前关于基底神经节的生理学研究和模型在神经元活动的哪些方面对帕金森病的病理生理学至关重要这一问题上存在分歧。有证据表明神经振荡和同步化在该疾病的发生中起核心作用。然而，帕金森震颤与基底神经节网络中的同步振荡并非严格相关。相反，基底神经节输出异常会导致丘脑 - 皮质处理异常，进而导致运动不能，这是帕金森病的主要负面症状。帕金森震颤可能是作为一种下游代偿机制而演变而来的。
