Baak J P, Fleege J C
Pathologisches Institut, Freies Universitätskrankenhaus, Amsterdam/Niederlande.
Verh Dtsch Ges Pathol. 1990;74:165-8.
The classical pathological diagnosis is of decisive importance for adequate therapy choice. Unfortunately, inconsistency in judgement of the same case and disagreement in diagnosis between different pathologists can be pronounced. Nevertheless, techniques of quantitative pathology largely improve the reliability of diagnosis because of their, in principle, high objectivity and reproducibility. Besides stereology, morphometry and flow cytometry recently also digital image processing, three dimensional laser scan microscopy and multimedial integrated image-database expert systems are becoming increasingly applicated. However, to gain maximum profit of these quantitative methods, sufficient measurement error handling is indispensable. In addition, concepts of standardisation and ongoing quality control should be available to assure confident measurements as a valuable aid in the diagnostic process.
经典的病理诊断对于选择恰当的治疗方法具有决定性意义。不幸的是，对同一病例判断的不一致以及不同病理学家之间诊断的分歧可能很明显。然而，定量病理学技术因其原则上具有较高的客观性和可重复性，在很大程度上提高了诊断的可靠性。除了体视学、形态计量学和流式细胞术外，近来数字图像处理、三维激光扫描显微镜和多媒体集成图像数据库专家系统也越来越得到应用。然而，为了从这些定量方法中获得最大收益，对测量误差进行充分处理是必不可少的。此外，应具备标准化概念和持续质量控制，以确保可靠的测量结果，作为诊断过程中的一项有价值的辅助手段。
