Pesch H J, Becker T, Bischoff W, Seibold H
Pathologisches Institut, Universität Erlangen-Nürnberg.
Verh Dtsch Ges Pathol. 1990;74:238-42.
To investigate the question as to a possible insufficiency of the osteoblasts with increasing age, autopsy material obtained from 105 deceased of both sexes at an age of 16 to 91 in whom clinically manifest bone diseases had been excluded, was studied. The structure of the spongy bone of the 3rd to 5th lumbar vertebral bodies (LVB) and of the 5th to 7th cervical vertebral bodies (CVB) was examined quantitatively-morphometrically, and the results were submitted to a statistical evaluation. In the three LVB, Vv, Sv and S/V behave in a similar manner. Here, Vv and Sv decrease after the age of 50 by more than 1/3, while S/V remains constant throughout live. In all the structural parameters, the three lower CVB have higher values than do the LVB. The age-dependent changes, in contrast, are only very slight. This differing behaviour of the spongy bone in the two regions of the spinal column is an expression of the characteristic loading forces in the respective regions: LVB loading is predominantly static, CVB loading mainly dynamic. Thus, from this functional point of view, physiological osteoporosis due to aging, so-called, is merely an expression of an aging bone adapting - in the same way as the bone of a young adult - to the current loading forces acting upon it.
为了研究随着年龄增长成骨细胞可能出现的功能不足问题，我们对105名年龄在16至91岁之间、临床排除明显骨病的男女死者的尸检材料进行了研究。对第三至第五腰椎椎体（LVB）和第五至第七颈椎椎体（CVB）的松质骨结构进行了定量形态学检查，并对结果进行了统计学评估。在三个腰椎椎体中，Vv、Sv和S/V的变化趋势相似。50岁以后，Vv和Sv下降超过1/3，而S/V在整个生命过程中保持不变。在所有结构参数方面，三个较低的颈椎椎体的值均高于腰椎椎体。相比之下，年龄相关的变化非常轻微。脊柱两个区域的松质骨这种不同的表现，反映了各自区域的特征性负荷力：腰椎椎体的负荷主要是静态的，颈椎椎体的负荷主要是动态的。因此，从这个功能角度来看，所谓的因衰老导致的生理性骨质疏松，仅仅是衰老骨骼像年轻成年人的骨骼一样适应当前作用于其上的负荷力的一种表现。
