Neifer Stefan, Somogyi Sybille, Schlote Frank, Berg Thomas, Poggensee Gabriele, Kuecherer Claudia
Medical Laboratory Prenzlauer Berg, Berlin, Germany.
AIDS. 2006 Nov 14;20(17):2231-3. doi: 10.1097/QAD.0b013e328010ac6f.
The evolution of a sexually transmitted multiresistant HIV-1 in a linked transmission chain was followed for 33 months to assess its potential to persist in the absence of treatment. The multiresistant HIV reverted slowly to wild type in reverse transcriptase (positions 44, 67, 74, 118) rendering the virus only susceptible to lamivudine/emtricitabine. Persistence of the replication-competent resistant HIV increases its potential to spread further and strengthens the importance of resistance testing in newly infected patients.
在一个关联传播链中，对一种性传播的多重耐药HIV-1进行了33个月的追踪，以评估其在未接受治疗情况下持续存在的可能性。这种多重耐药HIV在逆转录酶（第44、67、74、118位）上缓慢地回复到野生型，使得该病毒仅对拉米夫定/恩曲他滨敏感。具有复制能力的耐药HIV的持续存在增加了其进一步传播的可能性，并强化了对新感染患者进行耐药性检测的重要性。
