Delaugerre Constance, Marcelin Anne-Genevieve, Soulié Cathia, Chaix Marie-Laure, Katlama Christine, Girard Pierre-Marie, Calvez Vincent, Morand-Joubert Laurence
Department of Virology-EA3620, Necker Hospital, Paris, France.
AIDS. 2007 Jun 19;21(10):1365-7. doi: 10.1097/QAD.0b013e3280d6edf1.
Multidrug resistant HIV-1 acquired at the time of primary infection in two patients persisted for at least 5 years with and without treatment. In each patient, only one back mutation to wild-type codon in the protease gene occurred, and that was concomitantly associated with a marked CD4 cell count decrease. In both cases, infection was caused by CCR5 viruses and no rapid clinical progression to AIDS after primary infection was observed.
两名患者在初次感染时获得的多重耐药HIV-1，无论是否接受治疗，都持续存在了至少5年。在每名患者中，蛋白酶基因仅出现了一次向野生型密码子的反向突变，且这与CD4细胞计数显著下降同时发生。在这两个病例中，感染均由CCR5病毒引起，初次感染后未观察到迅速进展至艾滋病的临床情况。
