Ellender G, Feik S A, Gaviria C
Restorative Dentistry, School of Dental Science, University of Melbourne.
Aust Dent J. 1990 Dec;35(6):497-504. doi: 10.1111/j.1834-7819.1990.tb04679.x.
The biological responses to some dental amalgams were determined in vivo and compared with those of dental porcelain. The technique of implantation employed in the study addressed some of the vagaries of the Recommended Standard Practices for Biological Evaluation of Dental Materials (RSP) and considered both cellular responses (inflammation, infiltration and fibrogenic cell activity) and the organizational status of the resultant encapsulation. The implantation sites for both the experimental and control were biogeometrically similar, unlike those currently recommended in RSP. At the end of the test period, all the dental amalgams tested caused minor responses reflected by the formation of thin capsules with an acceptable matrix organization. The Australian manufactured dental amalgams--Permite C, Lojic, F400, New Ultrafine and GS80 all produced even capsules with quiescent cells. By one hundred days, the capsule around Dispersalloy, although generally well formed, showed some areas of cellular activity and matrix variability. The biological responses to all the dental amalgams examined were mild and considered to be acceptable for clinical usage. The matrix organization of enveloping capsules must be considered in the determination of the biocompatibility of a dental restorative material.
在体内确定了对某些牙科汞合金的生物学反应，并与牙科瓷器的反应进行了比较。该研究中采用的植入技术解决了牙科材料生物学评价推荐标准操作（RSP）中的一些变化无常的情况，并考虑了细胞反应（炎症、浸润和纤维原细胞活性）以及所形成包囊的组织状态。与RSP目前推荐的不同，实验和对照的植入部位在生物几何学上相似。在试验期结束时，所有测试的牙科汞合金都引起了轻微反应，表现为形成了具有可接受基质组织的薄包囊。澳大利亚生产的牙科汞合金——Permite C、Lojic、F400、新型超细合金和GS80都产生了含有静止细胞的均匀包囊。到100天时，Dispersalloy周围的包囊虽然总体形成良好，但显示出一些细胞活性和基质变异性区域。对所有检查的牙科汞合金的生物学反应都很轻微，被认为在临床上可以接受。在确定牙科修复材料的生物相容性时，必须考虑包囊的基质组织。
