Giulazian N M, Davtian T K, Pak S G
Klin Lab Diagn. 2006 Aug(8):25-8.
The in vitro induction of granulocytes in the presence of high and low concentrations of lipopolysaccharides (LPS) allowed the authors to study a dose-dependent apoptotic response in the population of intact cells and in that of primed cells in the period of convalescence in patients with Salmonella infection. An experimental system was used to study a respiratory burst and granulocytic apoptosis in the presence of hypothalamic neuropeptides. The clinical manifestations of the diseases were studied in 32 inpatients. It was shown that there was an increase in the sensitivity of granulocytes to the apoptotic action of low, suboptimal doses (100 ng) of S. enteritidis LPS in patients with salmonellosis at convalescence. This correlates with the severity of a clinical course of the experienced disease and with the suppressed sensitivity of apoptosis to the optimal doses (1000 ng) LPS.
在高浓度和低浓度脂多糖（LPS）存在的情况下对粒细胞进行体外诱导，使作者能够研究沙门氏菌感染患者康复期完整细胞群体和致敏细胞群体中的剂量依赖性凋亡反应。使用实验系统研究下丘脑神经肽存在时的呼吸爆发和粒细胞凋亡。对32名住院患者的疾病临床表现进行了研究。结果表明，在恢复期的沙门氏菌病患者中，粒细胞对低剂量、次优剂量（100 ng）肠炎沙门氏菌LPS的凋亡作用敏感性增加。这与所经历疾病的临床病程严重程度以及凋亡对最佳剂量（1000 ng）LPS的敏感性降低相关。
