与癌相比，具有严重异型性的人类大肠腺瘤中c-K-ras 2基因点突变频率更高。
Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas.
作者信息
Ando M, Maruyama M, Oto M, Takemura K, Endo M, Yuasa Y
机构信息
Department of Hygiene and Oncology, Tokyo Medical and Dental University School of Medicine.
出版信息
Jpn J Cancer Res. 1991 Mar;82(3):245-9. doi: 10.1111/j.1349-7006.1991.tb01836.x.
Abstract
Human colorectal carcinomas may be induced from adenomas or they may occur de novo. To examine which is the main pathway, we analyzed point mutations at codon 12 in the c-K-ras 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. The c-K-ras 2 codon 12 mutation frequency was 0/30 in normal tissues, 0/17 in adenomas with mild atypia, 3/37 (8.1%) in adenomas with moderate atypia, 15/18 (83.3%) in adenomas with severe atypia, 19/73 (26.0%) in primary carcinomas and 3/13 (23.1%) in metastatic tumors. The mutation frequency in adenomas with severe atypia was much higher than that in carcinomas. These results indicate that many colorectal carcinomas may not be induced through adenomas with severe atypia.
摘要
人类结直肠癌可能由腺瘤诱发，也可能原发产生。为了探究哪条是主要途径，我们分析了73例结直肠癌、13例转移瘤、72例腺瘤和30例正常组织中c-K-ras 2基因第12密码子的点突变情况。c-K-ras 2基因第12密码子的突变频率在正常组织中为0/30，轻度异型增生腺瘤中为0/17，中度异型增生腺瘤中为3/37（8.1%），重度异型增生腺瘤中为15/18（83.3%），原发性癌中为19/73（26.0%），转移瘤中为3/13（23.1%）。重度异型增生腺瘤中的突变频率远高于癌中的突变频率。这些结果表明，许多结直肠癌可能并非通过重度异型增生腺瘤诱发产生。
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