人类Ki-ras原癌基因及一个相关的加工假基因的结构与组织

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.

作者信息

McGrath J P, Capon D J, Smith D H, Chen E Y, Seeburg P H, Goeddel D V, Levinson A D

出版信息

Nature. 1983;304(5926):501-6. doi: 10.1038/304501a0.

Abstract

Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing.

摘要

对与柯斯顿鼠肉瘤病毒转化基因相关的两个人类基因座的组织和核苷酸序列分析表明，其中一个是功能基因，另一个是加工过的假基因。功能基因的两个最终编码外显子似乎是通过复制产生的。包含其中一个或另一个复制外显子的差异剪接mRNA可能是产生病毒转化基因和假基因的中间体。这表明功能基因可能根据RNA剪接模式指定两种相关多肽中的任何一种。