人类结直肠癌中ras基因突变的发生率。
Prevalence of ras gene mutations in human colorectal cancers.
作者信息
Bos J L, Fearon E R, Hamilton S R, Verlaan-de Vries M, van Boom J H, van der Eb A J, Vogelstein B
出版信息
Nature. 1987;327(6120):293-7. doi: 10.1038/327293a0.
DOI:10.1038/327293a0
PMID:3587348
Abstract
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
摘要
DNA杂交分析和组织切片技术相结合的方法表明，超过三分之一的人类结肠直肠癌中存在ras基因突变，大多数突变发生在c-Ki-ras基因的第12密码子处，并且这些突变通常在恶性肿瘤发展之前出现。
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