Bos J L, Fearon E R, Hamilton S R, Verlaan-de Vries M, van Boom J H, van der Eb A J, Vogelstein B
Nature. 1987;327(6120):293-7. doi: 10.1038/327293a0.
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
DNA杂交分析和组织切片技术相结合的方法表明，超过三分之一的人类结肠直肠癌中存在ras基因突变，大多数突变发生在c-Ki-ras基因的第12密码子处，并且这些突变通常在恶性肿瘤发展之前出现。
