John John P, Wang Lei, Moffitt Amanda J, Singh Harmeeta K, Gado Mokhtar H, Csernansky John G
Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560 029, Karnataka, India.
Psychiatry Res. 2006 Dec 1;148(2-3):151-63. doi: 10.1016/j.pscychresns.2006.05.006. Epub 2006 Nov 7.
Precise rules for locating the anatomical boundaries of the dorsolateral prefrontal cortex (DLPFC) or its subdivisions, i.e., superior, inferior and middle frontal gyri (SFG, IFG and MFG) on magnetic resonance images (MRI), have not been defined. The present study describes the inter-rater reliability of manual segmentation of the SFG, IFG and MFG using guidelines based on sulcal-gyral anatomical boundaries as well as the cytoarchitectonic features of the sub-regions of the prefrontal cortex (PFC). Variations in the application of these guidelines in different subjects to account for normal sulcal variability were developed using the atlas of Ono et al. (Ono, M., Kubik, S., Abernathey, C.D., 1990. Atlas of the Cerebral Sulci. Georg Thieme Verlag, New York). Based on previous cytoarchitectonic studies, the coronal plane of the anterior termination of olfactory sulcus (ATOS) was used as a landmark for delimiting the boundary between the frontal pole (FP) and the frontal gyri. The left hemisphere gray-matter volumes of the SFG, IFG and MFG were determined using a set of 10 MRIs (5 normal and 5 schizophrenia subjects) by two trained raters independently. The intra-class correlation coefficients (ICC) for the SFG, IFG and MFG volumes by the two raters were 0.97, 0.94 and 0.93, respectively. Thus, we describe a reliable method of parcellating the SFG, IFG and MFG, which constitute the DLPFC, a brain region involved in a variety of neuropsychiatric conditions.
在磁共振成像（MRI）上，用于定位背外侧前额叶皮层（DLPFC）或其细分区域，即额上回、额中回和额下回（SFG、IFG和MFG）的解剖边界的精确规则尚未明确。本研究描述了使用基于脑沟-脑回解剖边界以及前额叶皮层（PFC）子区域细胞构筑特征的指南，对SFG、IFG和MFG进行手动分割的评分者间信度。利用小野等人的图谱（小野，M.，库比克，S.，阿伯纳西，C.D.，1990年。《脑沟图谱》。乔治·蒂姆出版社，纽约），制定了在不同受试者中应用这些指南以考虑正常脑沟变异性的方法。基于先前的细胞构筑学研究，嗅沟前终末（ATOS）的冠状平面被用作界定额极（FP）和额回之间边界的标志。由两名经过培训的评分者独立使用一组10幅MRI图像（5名正常受试者和5名精神分裂症受试者）确定SFG、IFG和MFG的左半球灰质体积。两名评分者对SFG、IFG和MFG体积的组内相关系数（ICC）分别为0.97、0.94和0.93。因此，我们描述了一种可靠的划分构成DLPFC的SFG、IFG和MFG的方法，DLPFC是一个涉及多种神经精神疾病的脑区。
