胞质（依赖NADH）兔肌甘油磷酸脱氢酶的新型竞争性抑制剂。
New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.
作者信息
Fonvielle Matthieu, Therisod Helene, Hemery Marion, Therisod Michel
机构信息
Equipe Chimie Bioorganique et Bioinorganique, ICMMO, Univ Paris-Sud, UMR 8182, F-91405 Orsay, France.
出版信息
Bioorg Med Chem Lett. 2007 Jan 15;17(2):410-3. doi: 10.1016/j.bmcl.2006.10.030. Epub 2006 Oct 17.
PMID:17088060
Abstract
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 microM, might be of interest as an anti-obesity drug.
摘要
我们报告了胞质（依赖NADH的）磷酸甘油脱氢酶新竞争性抑制剂的合成及生化评估。测试效果最佳的化合物——膦酰基丙酰异羟肟酸，其抑制常数为6微摩尔，有望成为一种抗肥胖药物。
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