Wahlund Lars-Olof, Almkvist Ove, Blennow Kaj, Engedahl Knut, Johansson Aki, Waldemar Gunhild, Wolf Henrike
Department of Neurobiology, Caring Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Top Magn Reson Imaging. 2005 Dec;16(6):427-37. doi: 10.1097/01.rmr.0000245463.36148.12.
The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease.
In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way.
However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.
磁共振成像在痴呆症检查中的诊断效用最近有所提高。其基本用途是排除脑部占位性病变。然而，磁共振成像为研究特定脑区萎缩提供了重要契机。内侧颞叶萎缩是否可作为阿尔茨海默病的早期诊断标志物备受关注。
在本评估中，我们采用循证技术并查阅了400多篇涉及该问题的文章。我们的主要发现是，在研究脑区时使用了多种方法，这使得难以系统地提取确凿信息。
然而，我们能够得出结论，海马体萎缩可将阿尔茨海默病患者与健康受试者区分开来，但由于关于内侧颞叶萎缩作为更一般情况下诊断标志物的有用性的研究不足，缺乏证据支持。
