Anderson Valerie C, Litvack Zachary N, Kaye Jeffrey A
Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA.
Top Magn Reson Imaging. 2005 Dec;16(6):439-52. doi: 10.1097/01.rmr.0000245458.05654.d0.
The noninvasive, nonradioactive, quantitative nature of magnetic resonance techniques has propelled them to the forefront of neuroscience and neuropsychiatric research. In particular, recent advances have confirmed their enormous potential in patients with Alzheimer disease (AD). Structural and functional magnetic resonance (MR) imaging have demonstrated significant correlation with clinical outcomes and underlying pathology and are used increasingly in the AD clinic. This review will highlight the role of high-resolution structural MR imaging and functional magnetic resonance imaging in the identification of atrophic and hemodynamic changes in AD and their potential as diagnostic biomarkers and surrogates of therapeutic response. Advanced MR techniques based on diffusion, perfusion, and neurochemical abnormalities in the aging brain will be presented briefly. These newer techniques continue to expand our understanding of neuropathology in the aging brain and are likely to play an important clinical role in the future.
磁共振技术具有非侵入性、无放射性且可定量的特性，这使其在神经科学和神经精神疾病研究领域处于前沿地位。特别是，最近的进展证实了它们在阿尔茨海默病（AD）患者中具有巨大潜力。结构和功能磁共振（MR）成像已显示出与临床结果及潜在病理存在显著相关性，并且在AD临床中越来越多地被使用。本综述将重点介绍高分辨率结构MR成像和功能磁共振成像在识别AD萎缩性和血流动力学变化方面的作用，以及它们作为诊断生物标志物和治疗反应替代指标的潜力。还将简要介绍基于衰老大脑中扩散、灌注和神经化学异常的先进MR技术。这些更新的技术不断拓展我们对衰老大脑神经病理学的理解，并且未来可能会发挥重要的临床作用。
