用于治疗与脑衰老相关主要疾病的超顺磁性氧化铁纳米颗粒标记干细胞疗法：一项系统综述。
Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review.
作者信息
Alvarim Larissa T, Nucci Leopoldo P, Mamani Javier B, Marti Luciana C, Aguiar Marina F, Silva Helio R, Silva Gisele S, Nucci-da-Silva Mariana P, DelBel Elaine A, Gamarra Lionel F
机构信息
Hospital Israelita Albert Einstein, São Paulo, Brazil ; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
出版信息
Int J Nanomedicine. 2014 Aug 11;9:3749-70. doi: 10.2147/IJN.S65616. eCollection 2014.
The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.
评估细胞疗法对与衰老大脑相关疾病的神经系统结构和功能再生功效的临床试验有所增加，这是众所周知的。然而，关于使用何种最佳细胞类型或这些干细胞归巢的最佳方法，结果尚无定论。本系统综述分析了已发表的关于超顺磁性氧化铁纳米颗粒（SPION）标记的干细胞作为治疗脑疾病（如缺血性中风、帕金森病、肌萎缩侧索硬化症和痴呆症）的数据。本综述强调了干细胞在逆转衰老过程和脑衰老病理生理学方面的治疗作用，同时强调了纳米技术作为监测干细胞在脑受影响区域迁移的重要工具。
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