来自印度西部的佩吉特氏病。
Paget's disease from Western India.
作者信息
Joshi Shashank R, Ambhore S, Butala N, Patwardhan M, Kulkarni M, Pai B, Karne R
机构信息
Lilavati and Bhatia Hospital, Mumbai.
出版信息
J Assoc Physicians India. 2006 Jul;54:535-8.
AIM AND OBJECTIVE
To prospectively study prevalence of Paget's disease from Western India.
METHODS AND MATERIALS
Seventeen consecutive cases from Western India from 1998 to 2005 are analysed for the clinical, biochemical, skeletal profile. Seventeen cases (15 males & 2 females) with mean age of 62 were diagnosed
RESULTS
The Western Indian cohort of Paget's disease has male preponderance with a mean age of 62 years at onset. Its clinical features are pain, fracture and typical skeletal involvement. It is a non-familial, polyostotic disease with pelvis, skull, spine and femur being the commonly affected bone sites. Elevated alkaline phosphatase is typical which responds well to bisphosphonate therapy in 6 months. Most cases do well with low dose alendronate (10-20mg/day).
CONCLUSIONS
Paget's disease in western India is rare with classical clinical, radiological and biochemical features and responds well to low dose alendronate therapy. In eight years, seventeen cases of Paget's disease were seen from Western India indicating though still rare is present in this population of Western India.
目的
前瞻性研究印度西部佩吉特病的患病率。
方法与材料
对1998年至2005年来自印度西部的17例连续病例进行临床、生化和骨骼方面的分析。确诊17例（15例男性和2例女性），平均年龄62岁。
结果
印度西部佩吉特病患者以男性居多，发病平均年龄为62岁。其临床特征为疼痛、骨折和典型的骨骼受累。这是一种非家族性、多骨型疾病，骨盆、颅骨、脊柱和股骨是常见的受累骨骼部位。碱性磷酸酶升高很典型，在6个月内对双膦酸盐治疗反应良好。大多数病例使用低剂量阿仑膦酸钠（10 - 20毫克/天）效果良好。
结论
印度西部的佩吉特病较为罕见，具有典型的临床、放射学和生化特征，对低剂量阿仑膦酸钠治疗反应良好。在八年时间里，从印度西部发现了17例佩吉特病病例，表明该病在印度西部人群中虽然仍然罕见，但确实存在。
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