Bhatt K, Balakrishnan C, Mangat G, Bajan K, Ashavaid T, Joshi V R
Rheumatology Division, PD Hinduja Hospital and MRC, Veer Savarkar Marg, Mumbai.
J Assoc Physicians India. 2006 Jul;54:571-4.
Paget's disease is uncommon in Asians. We present 3 patients with varying manifestations. A 50 years old lady was detected to have raised alkaline phosphatase at a routine health check-up. Isoenzyme studies confirmed its bony origin. Bone scan revealed polyostotic disease. A 65 years old male patient with known Paget's disease of 6 years duration presented with pelvic girdle pain, progressive increase in alkaline phosphatase levels and worsening bone scan. A 45 years old male was admitted with chest pain. Cardiac evaluation was normal. Bone scan picked up a cough fracture in the left 7th rib and an incidental Paget's disease of the skull. All three had elevated markers of bone metabolism in the serum and urine. With monthly intravenous pamidronate there was significant improvement in the bone markers and follow-up bone scans.
佩吉特病在亚洲人中并不常见。我们报告了3例表现各异的患者。一名50岁女性在常规健康检查中被检测出血清碱性磷酸酶升高。同工酶研究证实其来源于骨骼。骨扫描显示为多骨型病变。一名65岁男性患者，已知患有佩吉特病6年，出现骨盆带疼痛、碱性磷酸酶水平逐渐升高以及骨扫描结果恶化。一名45岁男性因胸痛入院。心脏评估正常。骨扫描发现左侧第7肋骨有骨折以及颅骨有偶然发现的佩吉特病。所有3例患者血清和尿液中的骨代谢标志物均升高。每月静脉注射帕米膦酸后，骨标志物和随访骨扫描有显著改善。
