Kastenmayer Robin J, Fain Michele A, Perdue Kathy A
National Institute of Health, National Institute of Allergy and Infectious Diseases, Rocville, Maryland, USA.
J Am Assoc Lab Anim Sci. 2006 Nov;45(6):8-12.
Idiopathic ulcerative dermatitis is a well-recognized disease in C57BL mice and related strains. This disease manifests as a pruritic dermatitis with resulting self-mutilation, dermal ulceration, necrosis, and fibrosis. Ulcerative dermatitis has the ability to confound ongoing research by causing systemic pathologic changes, such as lymphadenopathy and splenomegaly. Although various treatments have been described, none has been curative consistently; therefore, minimizing negative effects on research through prevention of disease is ideal. To identify etiologic factors, we conducted a 2-y retrospective study of 1352 mice with a C57BL/6 genetic background; these mice demonstrated an overall prevalence of 4.1% and a seasonal effect with a peak incidence during midsummer. Corroborating previous studies, our study revealed a disease predilection for female mice. In contrast to prior reports, the disease prevalence was greatest in 10- to 16-mo-old mice. In addition, mice with a C57BL/6 background that were deficient in the gene for inducible nitric oxide synthase had a 50% disease incidence, suggesting a potential animal model for further characterizing the pathogenesis, prevention, and treatment of ulcerative dermatitis.
特发性溃疡性皮炎在C57BL小鼠及相关品系中是一种公认的疾病。这种疾病表现为瘙痒性皮炎，并伴有自残、皮肤溃疡、坏死和纤维化。溃疡性皮炎能够通过引起全身病理变化（如淋巴结病和脾肿大）干扰正在进行的研究。尽管已经描述了各种治疗方法，但没有一种能始终治愈；因此，通过预防疾病将对研究的负面影响降至最低是理想的。为了确定病因，我们对1352只具有C57BL/6基因背景的小鼠进行了一项为期2年的回顾性研究；这些小鼠的总体患病率为4.1%，且有季节性影响，仲夏发病率最高。与先前的研究一致，我们的研究揭示了该疾病对雌性小鼠的偏好。与先前的报道相反，该疾病在10至16月龄的小鼠中患病率最高。此外，诱导型一氧化氮合酶基因缺陷的C57BL/6背景小鼠的发病率为50%，这表明它是进一步表征溃疡性皮炎发病机制、预防和治疗的潜在动物模型。
