Alvarado Cynthia G, Franklin Craig L, Dixon Lonny W
Department of Veterinary Pathobiology, Comparative Medicine Program, University of Missouri-Columbia, Columbia, Missouri, USA; The Jackson Laboratory, Bar Harbor, Maine, USA.
Department of Veterinary Pathobiology, Comparative Medicine Program, University of Missouri-Columbia, Columbia, Missouri, USA.
J Am Assoc Lab Anim Sci. 2016;55(4):462-6.
Ulcerative dermatitis (UD) is an idiopathic disease that affects C57BL/6 mice and those having a B6 background. The hallmark of UD is pruritus, which leads to self-mutilation and epidermal ulceration typically in the intrascapular region. Although several treatments for UD have been published, some involve the use of pharmacologic agents that might confound research results. In this retrospective study, we evaluated nail trimming to determine whether this conservative treatment approach improved the resolution rate of UD at our institution compared with that of untreated mice or those that received oral or topical antibiotics. Our findings show that the incidence of resolution of UD was significantly greater and that the time to resolution was shorter in mice treated with nail trimming compared with other groups. These findings support the use of nail trimming as an effective conservative treatment option for UD in B6 mice.
溃疡性皮炎（UD）是一种特发性疾病，会影响C57BL/6小鼠以及具有B6背景的小鼠。UD的标志是瘙痒，这通常会导致自残以及肩胛间区域的表皮溃疡。尽管已经发表了几种治疗UD的方法，但有些方法涉及使用可能会混淆研究结果的药物。在这项回顾性研究中，我们评估了剪指甲，以确定与未治疗的小鼠或接受口服或局部抗生素治疗的小鼠相比，这种保守的治疗方法是否能提高我们机构中UD的治愈率。我们的研究结果表明，与其他组相比，接受剪指甲治疗的小鼠中UD治愈的发生率显著更高，且治愈时间更短。这些研究结果支持将剪指甲作为B6小鼠中UD的一种有效的保守治疗选择。
