Jia Li-Na, Wang Xing-Juan
Department of Gynecology of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhong Xi Yi Jie He Xue Bao. 2006 Nov;4(6):585-8. doi: 10.3736/jcim20060608.
To investigate the therapeutic effect of treatment based on syndrome differentiation and its influence on the serum levels of testosterone and insulin in women with polycystic ovary syndrome (PCOS).
Forty-three women, diagnosed with PCOS as well as syndrome of kidney yin deficiency or syndrome of spleen qi deficiency, were enrolled in the study. Twenty-five PCOS women with syndrome of kidney yin deficiency were treated with traditional Chinese herbs for nourishing yin to reduce fire (nourishing yin group), and 18 PCOS women with syndrome of spleen qi deficiency were treated with herbs for invigorating spleen and replenishing qi (replenishing qi group). Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and the serum levels of insulin and testosterone before and after treatment were detected.
Among the 43 cases, 20 cases had high serum testosterone level, in which 13 cases with syndrome of kidney yin deficiency, 7 cases with syndrome of spleen qi deficiency, but the difference had no statistic significance; 17 cases had high serum insulin level, in which 11 cases with syndrome of spleen qi deficiency, 6 cases with syndrome of kidney yin deficiency, the difference had statistic significance (P<0.05). In nourishing yin group, the serum levels of insulin and testosterone declined after treatment (P<0.05), and BMI, WHR and WC showed no significant changes. In replenishing qi group, the serum level of insulin declined after treatment (P<0.01), and BMI, WHR, WC and the serum level of testosterone showed no significant changes.
Traditional Chinese herbs for nourishing yin to reduce fire can significantly reduce the serum levels of testosterone and insulin in PCOS women with syndrome of kidney yin deficiency, and herbs for invigorating spleen and replenishing qi can significantly reduce the serum level of insulin in PCOS women with syndrome of spleen qi deficiency.
探讨辨证论治对多囊卵巢综合征（PCOS）女性睾酮和胰岛素血清水平的治疗效果及其影响。
纳入43例诊断为PCOS且伴有肾阴虚证或脾气虚证的女性。25例伴有肾阴虚证的PCOS女性采用滋阴降火的中药治疗（滋阴组），18例伴有脾气虚证的PCOS女性采用健脾益气的中药治疗（益气组）。检测治疗前后的体重指数（BMI）、腰臀比（WHR）、腰围（WC）以及胰岛素和睾酮的血清水平。
43例中，血清睾酮水平高者20例，其中肾阴虚证13例，脾气虚证7例，但差异无统计学意义；血清胰岛素水平高者17例，其中脾气虚证11例，肾阴虚证6例，差异有统计学意义（P<0.05）。滋阴组治疗后胰岛素和睾酮血清水平下降（P<0.05），BMI、WHR和WC无明显变化。益气组治疗后胰岛素血清水平下降（P<0.01），BMI、WHR、WC和睾酮血清水平无明显变化。
滋阴降火的中药可显著降低伴有肾阴虚证的PCOS女性的睾酮和胰岛素血清水平，健脾益气的中药可显著降低伴有脾气虚证的PCOS女性的胰岛素血清水平。
