Ruan Jue, Guo Yiran, Li Heng, Hu Yafeng, Song Fei, Huang Xin, Kristiensen Karsten, Bolund Lars, Wang Jun
Beijing Institute of Genomics of the Chinese Academy of Sciences, Beijing Genomics Institute, Beijing 101300, China.
Nucleic Acids Res. 2007 Jan;35(Database issue):D654-7. doi: 10.1093/nar/gkl808. Epub 2006 Nov 7.
Pig Genomic Information System (PigGIS) is a web-based depository of pig (Sus scrofa) genomic learning mainly engineered for biomedical research to locate pig genes from their human homologs and position single nucleotide polymorphisms (SNPs) in different pig populations. It utilizes a variety of sequence data, including whole genome shotgun (WGS) reads and expressed sequence tags (ESTs), and achieves a successful mapping solution to the low-coverage genome problem. With the data presently available, we have identified a total of 15 700 pig consensus sequences covering 18.5 Mb of the homologous human exons. We have also recovered 18 700 SNPs and 20 800 unique 60mer oligonucleotide probes for future pig genome analyses. PigGIS can be freely accessed via the web at http://www.piggis.org/ and http://pig.genomics.org.cn/.
猪基因组信息系统（PigGIS）是一个基于网络的猪（野猪）基因组知识库，主要为生物医学研究而设计，用于从人类同源基因定位猪基因，并在不同猪群体中定位单核苷酸多态性（SNP）。它利用各种序列数据，包括全基因组鸟枪法（WGS）读数和表达序列标签（EST），并成功解决了低覆盖度基因组问题的映射方案。根据目前可用的数据，我们总共鉴定出15700条猪共有序列，覆盖了18.5 Mb的人类同源外显子。我们还获得了18700个SNP和20800个独特的60聚体寡核苷酸探针，用于未来的猪基因组分析。可通过以下网址免费访问PigGIS：http://www.piggis.org/ 和http://pig.genomics.org.cn/ 。
