Rosenbaum Michael, Nonas Cathy, Weil Richard, Horlick Mary, Fennoy Ilene, Vargas Ileana, Kringas Patricia
New York Presbyterian Hospital, New York, New York 10032, USA.
J Clin Endocrinol Metab. 2007 Feb;92(2):504-8. doi: 10.1210/jc.2006-1516. Epub 2006 Nov 7.
Risk factors for type 2 diabetes mellitus (T2DM) include obesity, family history, dyslipidemia, a proinflammatory state, impaired insulin secretory capacity, and insulin resistance.
The aim of this study was to examine the effects of a 3- to 4-month school-based intervention consisting of health, nutrition, and exercise classes plus an aerobic exercise program on diabetes risk.
This study was a randomized before/after controlled trial.
Seventy-three eighth-grade students in a predominantly Hispanic New York City public school were divided into a control group (studied twice without receiving the intervention) and an experimental group (studied before and after the intervention).
We measured body fatness (bioelectrical impedance), insulin sensitivity, beta-cell function (insulin release in response to an iv glucose load corrected for insulin sensitivity), lipid profiles, and circulating concentrations of IL-6, C-reactive protein, adiponectin, and TNF-alpha.
Participation in the intervention was associated with significant reductions in body fatness, insulin resistance, and circulating concentrations of C-reactive protein and IL-6, irrespective of somatotype on enrollment.
Short-term school-based health, nutrition, and exercise intervention is beneficial to all students and affects multiple diabetes risk factors.
2型糖尿病（T2DM）的危险因素包括肥胖、家族病史、血脂异常、促炎状态、胰岛素分泌能力受损和胰岛素抵抗。
本研究旨在探讨一项为期3至4个月的以学校为基础的干预措施的效果，该干预措施包括健康、营养和运动课程以及有氧运动计划对糖尿病风险的影响。
本研究为随机前后对照试验。
纽约市一所主要为西班牙裔学生的公立学校的73名八年级学生被分为对照组（未接受干预，进行两次测试）和实验组（在干预前后进行测试）。
我们测量了体脂（生物电阻抗）、胰岛素敏感性、β细胞功能（根据胰岛素敏感性校正后的静脉注射葡萄糖负荷后的胰岛素释放）、血脂谱以及白细胞介素-6、C反应蛋白、脂联素和肿瘤坏死因子-α的循环浓度。
参与干预与体脂、胰岛素抵抗以及C反应蛋白和白细胞介素-6的循环浓度显著降低相关，无论入学时的体型如何。
短期以学校为基础的健康、营养和运动干预对所有学生都有益，并影响多种糖尿病危险因素。
