Zhang Yunqing, Wu Yigao, Fei Xueyin, Li Yixuan, Li Yanchun, Yan Xu
China Basketball College, Beijing Sport University, Beijing 100084, China.
China Institute of Sports and Health Science, Beijing Sport University, Beijing 100084, China.
Life (Basel). 2023 Aug 18;13(8):1772. doi: 10.3390/life13081772.
Serum adiponectin plays a vital role in various physiological processes, such as anti-inflammatory, anti-atherosclerotic, anti-apoptotic and pro-angiogenic activities. Any abnormalities in its concentration can lead to adverse health outcomes, particularly in children and adolescents. Therefore, it is crucial to investigate factors influencing serum adiponectin concentrations in this population. The primary objective of this study was to systematically evaluate the impact of aerobic exercise on serum adiponectin concentrations in children and adolescents with obesity. To achieve this, a comprehensive literature search was conducted up to January 2023, utilising five databases: PubMed, Web of Science, Embase, Cochrane Library and Clinicaltrial.gov. The inclusion criteria involved studies that focused solely on aerobic exercise as an intervention for children and adolescents with obesity. Only studies that reported outcome indicators related to serum adiponectin were considered for analysis. The quality of the included studies was assessed using the Cochrane Risk of Bias (ROB) assessment tool, and statistical analysis was performed using RevMan 5.4.1 analysis software. This meta-analysis incorporated data from eight trials, involving a total of 272 subjects. The results demonstrated that aerobic training significantly increased serum adiponectin concentrations [standardized mean difference (SMD) = 0.85; 95% confidence interval (CI) = 0.33 to 1.37; I = 0%; = 0.001] in children and adolescents with obesity when compared to non-exercise controls. Furthermore, the magnitude of this effect appears to be influenced by the intensity of aerobic exercise, with higher-intensity aerobic exercise resulting in greater increases in serum adiponectin concentrations.
血清脂联素在各种生理过程中发挥着至关重要的作用，如抗炎、抗动脉粥样硬化、抗凋亡和促血管生成活性。其浓度的任何异常都可能导致不良健康后果，尤其是在儿童和青少年中。因此，研究影响该人群血清脂联素浓度的因素至关重要。本研究的主要目的是系统评估有氧运动对肥胖儿童和青少年血清脂联素浓度的影响。为实现这一目标，截至2023年1月进行了全面的文献检索，使用了五个数据库：PubMed、科学网、Embase、Cochrane图书馆和Clinicaltrial.gov。纳入标准包括仅将有氧运动作为肥胖儿童和青少年干预措施的研究。仅考虑报告了与血清脂联素相关结局指标的研究进行分析。使用Cochrane偏倚风险（ROB）评估工具评估纳入研究的质量，并使用RevMan 5.4.1分析软件进行统计分析。这项荟萃分析纳入了八项试验的数据，共涉及272名受试者。结果表明，与非运动对照组相比，有氧运动显著提高了肥胖儿童和青少年的血清脂联素浓度[标准化均值差（SMD）=0.85；95%置信区间（CI）=0.33至1.37；I² = 0%；P = 0.001]。此外，这种效应的大小似乎受有氧运动强度的影响，高强度有氧运动导致血清脂联素浓度升高幅度更大。
