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骨样骨瘤:114例患者的经皮激光消融及随访

Osteoid osteoma: percutaneous laser ablation and follow-up in 114 patients.

作者信息

Gangi Afshin, Alizadeh Houman, Wong Lisa, Buy Xavier, Dietemann Jean-Louis, Roy Catherine

机构信息

Department of Radiology, University Hospital of Strasbourg, 1 place de l'hopital, 67091 Strasbourg, France.

出版信息

Radiology. 2007 Jan;242(1):293-301. doi: 10.1148/radiol.2421041404. Epub 2006 Nov 7.

Abstract

PURPOSE

To retrospectively evaluate the effectiveness of interstitial laser ablation (ILA) as a curative treatment of osteoid osteoma.

MATERIALS AND METHODS

Ethical review board approval was obtained for the retrospective study. Informed consent was waived. From June 1994 to June 2004, 114 patients (mean age, 22.3 years) suspected of having osteoid osteoma underwent ILA with a diode laser (805 nm). An optical fiber was introduced into the nidus of the osteoid osteoma, and 400-3000 J of energy was delivered, depending on the size and location of the nidus. Twelve spinal osteoid osteomas were treated; in five of these cases, the nidus was located fewer than 8 mm from the adjacent nerve roots, and slow epidural or periradicular infusion of normal saline was used to avoid thermal damage to neurologic structures. Pain was evaluated with a visual analog scale (VAS) and medication. ILA was considered successful (score, 0) when complete pain relief was achieved (VAS score, <1) without medication.

RESULTS

One week after ILA, 112 patients had a score of 0. One week after ILA, one patient had pain that persisted for 2 months because of reflex sympathetic dystrophy. At follow-up (mean, 58.5 months; range, 13-130 months), six patients had recurrence of pain from 6 weeks to 27 months after the initial ILA. These recurrences were treated successfully with a second ILA. Only one unsuccessful treatment was encountered.

CONCLUSION

Percutaneous ILA is an effective treatment for osteoid osteoma.

摘要

目的

回顾性评估间质激光消融术(ILA)作为骨样骨瘤根治性治疗方法的有效性。

材料与方法

本回顾性研究获得了伦理审查委员会的批准,无需知情同意。1994年6月至2004年6月,114例疑似骨样骨瘤的患者(平均年龄22.3岁)接受了二极管激光(805nm)ILA治疗。将光纤插入骨样骨瘤的瘤巢,根据瘤巢的大小和位置输送400 - 3000焦耳的能量。治疗了12例脊柱骨样骨瘤;其中5例瘤巢距相邻神经根小于8mm,采用缓慢硬膜外或神经根周围输注生理盐水以避免对神经结构造成热损伤。采用视觉模拟评分法(VAS)和用药情况评估疼痛。当在未用药的情况下实现完全疼痛缓解(VAS评分<1)时,ILA被认为成功(评分为0)。

结果

ILA术后1周,112例患者评分为0。ILA术后1周,1例患者因反射性交感神经营养不良疼痛持续了2个月。在随访(平均58.5个月;范围13 - 130个月)时,6例患者在初次ILA后6周至27个月出现疼痛复发。这些复发通过第二次ILA成功治疗。仅遇到1例治疗失败。

结论

经皮ILA是治疗骨样骨瘤的有效方法。

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