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Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein.

作者信息

Ganter U, Strauss S, Jonas U, Weidemann A, Beyreuther K, Volk B, Berger M, Bauer J

机构信息

Psychiatrische Universitätsklinik, Universität Freiburg, Germany.

出版信息

FEBS Lett. 1991 Apr 22;282(1):127-31. doi: 10.1016/0014-5793(91)80460-k.

DOI:10.1016/0014-5793(91)80460-k
PMID:1709116
Abstract

Cultured human neuronal (SH-SY5Y neuroblastoma) cells synthesize and secrete the potent protease inhibitor alpha 2-macroglobulin (a2M) upon stimulation with interleukin-6 (IL-6) indicating that alpha 2-macroglobulin behaves as an acute-phase protein in the human central nervous system. Exogenous addition of a2M to the cultured neuronal cells resulted in only a slight inhibition of Alzheimer beta A4-amyloid precursor protein (APP) synthesis, but markedly inhibited its secretion pointing to the possibility that a2M may affect the proteolytic APP processing. Evidence is provided that IL-6 and a2M are involved in Alzheimer's disease pathogenesis.

摘要

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