Doroquez David B, Rebay Ilaria
Department of Biology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Crit Rev Biochem Mol Biol. 2006 Nov-Dec;41(6):339-85. doi: 10.1080/10409230600914344.
Metazoan development relies on a highly regulated network of interactions between conserved signal transduction pathways to coordinate all aspects of cell fate specification, differentiation, and growth. In this review, we discuss the intricate interplay between the epidermal growth factor receptor (EGFR; Drosophila EGFR/DER) and the Notch signaling pathways as a paradigm for signal integration during development. First, we describe the current state of understanding of the molecular architecture of the EGFR and Notch signaling pathways that has resulted from synergistic studies in vertebrate, invertebrate, and cultured cell model systems. Then, focusing specifically on the Drosophila eye, we discuss how cooperative, sequential, and antagonistic relationships between these pathways mediate the spatially and temporally regulated processes that generate this sensory organ. The common themes underlying the coordination of the EGFR and Notch pathways appear to be broadly conserved and should, therefore, be directly applicable to elucidating mechanisms of information integration and signaling specificity in vertebrate systems.
后生动物的发育依赖于保守信号转导通路之间高度调控的相互作用网络，以协调细胞命运决定、分化和生长的各个方面。在本综述中，我们讨论表皮生长因子受体（EGFR；果蝇EGFR/DER）与Notch信号通路之间复杂的相互作用，作为发育过程中信号整合的范例。首先，我们描述了在脊椎动物、无脊椎动物和培养细胞模型系统中的协同研究所得出的关于EGFR和Notch信号通路分子结构的当前理解状态。然后，特别聚焦于果蝇眼睛，我们讨论这些通路之间的协同、顺序和拮抗关系如何介导产生这个感觉器官的空间和时间调控过程。EGFR和Notch通路协调的共同主题似乎广泛保守，因此应直接适用于阐明脊椎动物系统中信息整合和信号特异性的机制。
