Galeone Carlotta, Pelucchi Claudio, Levi Fabio, Negri Eva, Franceschi Silvia, Talamini Renato, Giacosa Attilio, La Vecchia Carlo
Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy, Italy.
Am J Clin Nutr. 2006 Nov;84(5):1027-32. doi: 10.1093/ajcn/84.5.1027.
Interest in the potential benefits of allium vegetables, in particular, onion (Allium cepa) and garlic (Allium sativum), has its origin in antiquity, but the details of these benefits are still open to discussion.
We investigated the role of allium vegetables in the etiology of various neoplasms. Previous data are scanty and are based mainly on Chinese studies.
Using data from an integrated network of Italian and Swiss case-control studies, we analyzed the relation between frequency of onion and garlic use and cancer at several sites. We calculated odds ratios (ORs) by using multivariate logistic regression models that were adjusted for energy intake and other major covariates.
Consumption of onions varied between 0-14 and 0-22 portions/wk among cases and controls, respectively. The multivariate ORs for the highest category of onion and garlic intake were, respectively, 0.16 and 0.61 for cancer of the oral cavity and pharynx, 0.12 and 0.43 for esophageal cancer, 0.44 and 0.74 for colorectal cancer, 0.17 and 0.56 for laryngeal cancer, 0.75 and 0.90 for breast cancer, 0.27 and 0.78 for ovarian cancer, 0.29 and 0.81 for prostate cancer, and 0.62 and 0.69 for renal cell cancer.
This uniquely large data set from southern European populations shows an inverse association between the frequency of use of allium vegetables and the risk of several common cancers. Allium vegetables are a favorable correlate of cancer risk in Europe.
对葱属蔬菜潜在益处的关注，尤其是洋葱（葱属植物）和大蒜（大蒜），其起源可追溯到古代，但这些益处的细节仍有待讨论。
我们研究了葱属蔬菜在各种肿瘤病因学中的作用。先前的数据很少，且主要基于中国的研究。
利用来自意大利和瑞士病例对照研究综合网络的数据，我们分析了洋葱和大蒜的食用频率与多个部位癌症之间的关系。我们使用多变量逻辑回归模型计算优势比（OR），该模型对能量摄入和其他主要协变量进行了调整。
病例组和对照组中洋葱的消费量分别在每周0 - 14份和0 - 22份之间。洋葱和大蒜摄入量最高类别对应的多变量OR值，口腔和咽癌分别为0.16和0.61，食管癌分别为0.12和0.43，结直肠癌分别为0.44和0.74，喉癌分别为0.17和0.56，乳腺癌分别为0.75和0.90，卵巢癌分别为0.27和0.78，前列腺癌分别为0.29和0.81，肾细胞癌分别为0.62和0.69。
来自南欧人群的这一独特的大数据集显示，葱属蔬菜的食用频率与几种常见癌症的风险呈负相关。在欧洲，葱属蔬菜与癌症风险呈良好的相关性。
