Galeone Carlotta, Pelucchi Claudio, Dal Maso Luigino, Negri Eva, Montella Maurizio, Zucchetto Antonella, Talamini Renato, La Vecchia Carlo
Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, I-20156 Milan, Italy.
Public Health Nutr. 2009 Sep;12(9):1576-9. doi: 10.1017/S1368980008003820. Epub 2008 Nov 6.
The potential role of allium vegetables on endometrial cancer risk has been scarcely investigated and the results of previous Chinese studies are not easily applicable to Western populations. Therefore, we evaluated the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case-control study.
We analysed data from a multi-centre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions. Information was collected by trained interviewers using a validated and reproducible FFQ. Multivariate odds ratios and 95% confidence intervals were obtained after allowance for recognized confounding factors.
Compared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0.94 (95% CI 0.72, 1.21) for <2 portions/week and 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, with a significant inverse trend in risk (P = 0.01). The OR for an increment of one portion (i.e. 80 g) of onions per week was 0.81 (95% CI 0.70, 0.95). For garlic, the OR for successive categories of intake were 0.89 (95% CI 0.68, 1.15) for intermediate use and 0.62 (95% CI 0.42, 0.92) for high use, with a significant inverse trend in risk (P = 0.02).
Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer.
葱属蔬菜对子宫内膜癌风险的潜在作用鲜有研究，且以往中国研究的结果不易应用于西方人群。因此，我们利用一项意大利病例对照研究的数据，评估了洋葱和大蒜摄入量与子宫内膜癌之间的关系。
我们分析了一项多中心病例对照研究的数据，该研究纳入了454例子宫内膜癌病例和908例对照，这些病例和对照因各种急性非肿瘤性疾病入住同一医院。由经过培训的访谈员使用经过验证且可重复的食物频率问卷收集信息。在考虑公认的混杂因素后，获得多变量比值比和95%置信区间。
与不食用者相比，每周食用洋葱量<2份的子宫内膜癌患者的比值比为0.94（95%置信区间0.72，1.21），每周食用洋葱量≥2份的患者的比值比为0.40（95%置信区间0.22，0.72），风险呈显著的负相关趋势（P = 0.01）。每周增加一份（即80克）洋葱的比值比为0.81（95%置信区间0.70，0.95）。对于大蒜，中等食用量的比值比为0.89（95%置信区间0.68，1.15），高食用量的比值比为0.62（95%置信区间0.42，0.92），风险呈显著的负相关趋势（P = 0.02）。
我们的研究发现葱属蔬菜对子宫内膜癌风险具有一定的保护作用。
