Hsing Ann W, Chokkalingam Anand P, Gao Yu-Tang, Madigan M Patricia, Deng Jie, Gridley Gloria, Fraumeni Joseph F
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7234, USA.
J Natl Cancer Inst. 2002 Nov 6;94(21):1648-51. doi: 10.1093/jnci/94.21.1648.
Epidemiologic and laboratory studies suggest that allium vegetables and garlic constituents have antitumor effects. In a population-based, case-control study conducted in Shanghai, China, we investigated the association between intake of allium vegetables, including garlic, scallions, onions, chives, and leeks, and the risk of prostate cancer. We administered in-person interviews and collected information on 122 food items from 238 case subjects with incident, histologically confirmed prostate cancer and from 471 male population control subjects. Men in the highest of three intake categories of total allium vegetables (>10.0 g/day) had a statistically significantly lower risk (odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.34 to 0.76; P(trend)<.001) of prostate cancer than those in the lowest category (<2.2 g/day). Similar comparisons between categories showed reductions in risk for men in the highest intake categories for garlic (OR = 0.47, 95% CI = 0.31 to 0.71; P(trend)<.001) and scallions (OR = 0.30, 95% CI = 0.18 to 0.51; P(trend)<.001). The reduced risk of prostate cancer associated with allium vegetables was independent of body size, intake of other foods, and total calorie intake and was more pronounced for men with localized than with advanced prostate cancer.
流行病学和实验室研究表明，葱属蔬菜和大蒜成分具有抗肿瘤作用。在中国上海进行的一项基于人群的病例对照研究中，我们调查了包括大蒜、葱、洋葱、韭菜和韭葱在内的葱属蔬菜摄入量与前列腺癌风险之间的关联。我们进行了面对面访谈，收集了238例经组织学确诊为前列腺癌的新发病例和471名男性人群对照的122种食物摄入量信息。总葱属蔬菜摄入量最高的三个类别（>10.0克/天）的男性患前列腺癌的风险在统计学上显著低于摄入量最低的类别（<2.2克/天）（优势比[OR]=0.51，95%置信区间[CI]=0.34至0.76；P趋势<.001）。不同类别之间的类似比较显示，大蒜摄入量最高的类别（OR=0.47，95%CI=0.31至0.71；P趋势<.001）和葱（OR=0.30，95%CI=0.18至0.51；P趋势<.001）的男性风险降低。与葱属蔬菜相关的前列腺癌风险降低与体型、其他食物摄入量和总热量摄入无关，并且对于局限性前列腺癌男性比晚期前列腺癌男性更为明显。
