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本文引用的文献

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The HIV lipidome: a raft with an unusual composition.HIV脂质组：一个成分独特的脂筏。
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Broad neutralization and complement-mediated lysis of HIV-1 by PEHRG214, a novel caprine anti-HIV-1 polyclonal antibody.
AIDS. 2006 Feb 28;20(4):505-15. doi: 10.1097/01.aids.0000210604.78385.95.
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Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells.V组和X组分泌型磷脂酶A2可预防哺乳动物细胞中的腺病毒感染。
Biochem J. 2006 Jan 1;393(Pt 1):97-106. doi: 10.1042/BJ20050781.
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Neuronal expression and neuritogenic action of group X secreted phospholipase A2.X 组分泌型磷脂酶 A2 的神经元表达及促神经突生长作用
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Detection of antibody-dependent complement-mediated inactivation of both autologous and heterologous virus in primary human immunodeficiency virus type 1 infection.在原发性人类免疫缺陷病毒1型感染中检测抗体依赖性补体介导的自体和异源病毒失活。
J Virol. 2005 Mar;79(5):2823-30. doi: 10.1128/JVI.79.5.2823-2830.2005.
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Complement-opsonized HIV: the free rider on its way to infection.补体调理的HIV：感染之路上的搭便车者。
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7
pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN.严重急性呼吸综合征冠状病毒的pH依赖性进入由刺突糖蛋白介导，并通过树突状细胞经DC-SIGN转移而增强。
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Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.从转染了人IIA组和X组分泌型磷脂酶A2的哺乳动物细胞中释放花生四烯酸，主要发生在分泌过程中，且有胞质磷脂酶A2-α的参与。
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9
Specific antibody responses to vaccination with bivalent CM235/SF2 gp120: detection of homologous and heterologous neutralizing antibody to subtype E (CRF01.AE) HIV type 1.针对二价CM235/SF2 gp120疫苗接种的特异性抗体反应：检测对1型E亚型（CRF01.AE）HIV的同源和异源中和抗体。
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10
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.人源和鼠源的I、II、V、X和XII组分泌型磷脂酶A2全套的界面动力学和结合特性
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一种特异性分泌的人磷脂酶A2对1型人类免疫缺陷病毒的裂解作用。

Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.

作者信息

Kim Jae-Ouk, Chakrabarti Bimal K, Guha-Niyogi Anuradha, Louder Mark K, Mascola John R, Ganesh Lakshmanan, Nabel Gary J

机构信息

Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg. 40, MSC-3005, 40 Convent Dr., Bethesda, MD 20892-3005, USA.

出版信息

J Virol. 2007 Feb;81(3):1444-50. doi: 10.1128/JVI.01790-06. Epub 2006 Nov 8.

DOI:10.1128/JVI.01790-06
PMID:17093191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797512/
Abstract

Phospholipase A2 (PLA2) proteins affect cellular activation, signal transduction, and possibly innate immunity. A specific secretory PLA2, sPLA2-X, is shown here to neutralize human immunodeficiency virus type 1 (HIV-1) through degradation of the viral membrane. Catalytic function was required for antiviral activity, and the target cells of infection were unaffected. sPLA2-X potently reduced gene transfer of HIV-1 Env-pseudotyped lentivirus vectors and inhibited the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4+ T cells. Virions resistant to damage by antibody and complement were sensitive to lysis by sPLA2-X, suggesting a novel mechanism of antiviral surveillance independent of the acquired immune system.

摘要

磷脂酶A2（PLA2）蛋白影响细胞活化、信号转导，可能还影响固有免疫。本文显示一种特定的分泌型PLA2，即sPLA2-X，可通过降解病毒膜来中和1型人类免疫缺陷病毒（HIV-1）。抗病毒活性需要催化功能，且感染的靶细胞不受影响。sPLA2-X能有效降低HIV-1包膜假型慢病毒载体的基因转移，并抑制CCR5嗜性和CXCR4嗜性HIV-1在人CD4+T细胞中的复制。对抗体和补体损伤具有抗性的病毒粒子对sPLA2-X介导的裂解敏感，提示存在一种独立于获得性免疫系统的新型抗病毒监测机制。