Argenyi Z B, Balogh K
Department of Pathology, University of Iowa, Iowa City.
Am J Dermatopathol. 1991 Apr;13(2):115-21. doi: 10.1097/00000372-199104000-00003.
We report a case of collagenous spherulosis (CS) incidentally found in a chondroid syringoma of the facial skin. The lesion was studied by routine light microscopy, special stains, immunohistochemical methods, x-ray spectrophotometry, and electron microscopy. Light microscopy revealed solitary and confluent eosinophilic globules with radiating fibrillary structures within and around the lumina of the tubuloglandular components of chondroid syringoma. The fibrillary structures stained strongly for collagen and reticulin and less intensely for acidic mucopolysaccharides. Immunohistochemically, the globules were focally positive only for collagen type IV. Electron microscopy revealed radiating collagen fibers surrounded by basal lamina-like material. No inorganic crystals were identified by x-ray spectrophotometry. We conclude that (a) CS is not specific to breast but also occurs in chondroid syringomas; (b) the term collagenous spherulosis is appropriate because collagen fibers were demonstrated histochemically and ultrastructurally in the spherules; (c) CS appears to be associated with tubular epithelial structures; (d) there was no immunohistochemical evidence of myoepithelial differentiation. The etiology and significance of CS remain obscure.
我们报告1例在面部皮肤软骨样汗管瘤中偶然发现的胶原球状体病（CS）。通过常规光学显微镜、特殊染色、免疫组织化学方法、X射线分光光度法和电子显微镜对该病变进行了研究。光学显微镜显示，在软骨样汗管瘤的管状腺成分管腔内及周围有孤立的和融合的嗜酸性小球，伴有放射状纤维结构。纤维结构对胶原和网状纤维染色强烈，对酸性粘多糖染色较弱。免疫组织化学显示，小球仅局灶性表达IV型胶原。电子显微镜显示放射状胶原纤维被基底膜样物质包绕。X射线分光光度法未发现无机晶体。我们得出以下结论：（a）CS并非乳腺所特有，也可发生于软骨样汗管瘤；（b）胶原球状体病这一术语是恰当的，因为在小球中通过组织化学和超微结构证实了胶原纤维的存在；（c）CS似乎与管状上皮结构有关；（d）没有免疫组织化学证据表明存在肌上皮分化。CS的病因和意义仍不明确。
