Rabe Sirko, Dörfel Denise, Zöllner Tanja, Maercker Andreas, Karl Anke
Department of Psychology, Dresden University of Technology, Dresden, Germany.
Appl Psychophysiol Biofeedback. 2006 Dec;31(4):315-30. doi: 10.1007/s10484-006-9027-1. Epub 2006 Nov 9.
Persons with posttraumatic stress disorder (PTSD) have been shown to display elevated baseline cardiovascular activity and a heightened physiological reactivity to trauma-related stimuli. Study 1 examined differences in baseline heart rate (HR) and HR reactivity in 68 survivors of motor vehicle accidents (MVAs) and healthy controls without MVA. MVA survivors with PTSD (n=26), subsyndromal PTSD (n=22), traumatized controls without PTSD (non-PTSD with MVA, n=20) and healthy controls without MVA (HC, n=27) underwent measurement of HR during baseline and exposure to a neutral, positive, negative, and trauma-related picture. PTSD patients showed elevated baseline HR and increased HR reactivity only during exposure to the trauma-related picture. Study 2 investigated whether the elevated physiological responses observed in Study 1 normalized after cognitive behavioral therapy (CBT). We conducted a randomized, controlled treatment trial comparing CBT (n=17) to a Wait-list condition (WLC, n=18). Results showed a greater decrease in HR reactivity for CBT than for WLC. The change in HR reactivity was associated with clinical improvement.
创伤后应激障碍（PTSD）患者已被证明表现出基线心血管活动升高以及对创伤相关刺激的生理反应增强。研究1检查了68名机动车事故（MVA）幸存者与无MVA的健康对照者在基线心率（HR）和HR反应性方面的差异。患有PTSD的MVA幸存者（n = 26）、亚综合征PTSD患者（n = 22）、无PTSD的受创伤对照者（有MVA的非PTSD患者，n = 20）以及无MVA的健康对照者（HC，n = 27）在基线期以及暴露于中性、积极、消极和创伤相关图片时接受了HR测量。PTSD患者仅在暴露于创伤相关图片时表现出基线HR升高和HR反应性增加。研究2调查了在研究1中观察到的生理反应升高在认知行为疗法（CBT）后是否恢复正常。我们进行了一项随机对照治疗试验，将CBT组（n = 17）与等待名单组（WLC，n = 18）进行比较。结果显示，CBT组的HR反应性下降幅度大于WLC组。HR反应性的变化与临床改善相关。
