Solstad Trygve, Moser Edvard I, Einevoll Gaute T
Center for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway.
Hippocampus. 2006;16(12):1026-31. doi: 10.1002/hipo.20244.
Anatomical connectivity and recent neurophysiological results imply that grid cells in the medial entorhinal cortex are the principal cortical inputs to place cells in the hippocampus. The authors propose a model in which place fields of hippocampal pyramidal cells are formed by linear summation of appropriately weighted inputs from entorhinal grid cells. Single confined place fields could be formed by summing input from a modest number (10-50) of grid cells with relatively similar grid phases, diverse grid orientations, and a biologically plausible range of grid spacings. When the spatial phase variation in the grid-cell input was higher, multiple, and irregularly spaced firing fields were formed. These observations point to a number of possible constraints in the organization of functional connections between grid cells and place cells.
解剖学上的连接性以及近期的神经生理学研究结果表明，内嗅皮层中的网格细胞是海马体中位置细胞的主要皮层输入源。作者提出了一个模型，其中海马体锥体细胞的位置场是由来自内嗅网格细胞的适当加权输入的线性总和形成的。单个受限的位置场可以通过将来自数量适中（10 - 50个）、具有相对相似网格相位、不同网格方向以及生物学上合理的网格间距范围的网格细胞的输入进行求和而形成。当网格细胞输入中的空间相位变化较高时，会形成多个且间隔不规则的放电场。这些观察结果指出了网格细胞和位置细胞之间功能连接组织中的一些可能限制。
