Huber David E
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, United States.
Elife. 2025 May 19;13:RP95733. doi: 10.7554/eLife.95733.
A theory and neurocomputational model are presented that explain grid cell responses as the byproduct of equally dissimilar hippocampal memories. On this account, place and grid cells are best understood as the natural consequence of memory encoding and retrieval; a precise hexagonal grid is the exception rather than the rule, emerging when the animal explores a large surface that is devoid of landmarks and objects. In the proposed memory model, place cells represent memories that are conjunctions of both spatial and non-spatial attributes, and grid cells primarily represent the non-spatial attributes (e.g. sounds, surface texture, etc.) found throughout the two-dimensional recording enclosure. Place cells support memories of the locations where non-spatial attributes can be found (e.g. positions with a particular sound), which are arranged in a hexagonal lattice owing to memory encoding and consolidation processes (pattern separation) as applied to situations in which the non-spatial attributes are found at all locations of a two-dimensional surface. Grid cells exhibit their spatial firing pattern owing to feedback from hippocampal place cells (i.e. a hexagonal pattern of remembered locations for the non-spatial attribute represented by a grid cell). Model simulations explain a wide variety of results in the rodent spatial navigation literature.
本文提出了一种理论和神经计算模型，将网格细胞的反应解释为同等不同的海马体记忆的副产品。据此，位置细胞和网格细胞最好被理解为记忆编码和检索的自然结果；精确的六边形网格是例外而非规则，当动物探索一个没有地标和物体的大表面时才会出现。在所提出的记忆模型中，位置细胞代表空间和非空间属性结合的记忆，而网格细胞主要代表在二维记录环境中发现的非空间属性（如声音、表面纹理等）。位置细胞支持对可找到非空间属性的位置的记忆（如具有特定声音的位置），由于应用于非空间属性在二维表面所有位置都被发现的情况的记忆编码和巩固过程（模式分离），这些记忆以六边形晶格排列。网格细胞由于海马体位置细胞的反馈而呈现其空间放电模式（即由网格细胞代表的非空间属性的记忆位置的六边形模式）。模型模拟解释了啮齿动物空间导航文献中的各种结果。
