Lundberg Rebecca, Brytting Maria, Dahlgren Liselotte, Kanter-Lewensohn Lena, Schloss Lottie, Dalianis Tina, Ragnarsson-Olding Boel
Department of Virology, Swedish Institute for Infectious Disease Control, Solna.
Anticancer Res. 2006 Sep-Oct;26(5B):3627-31.
UV-radiation is the most important causative factor for malignant melanomas of the skin. However, this is not the case for melanomas on sun-sheltered body surfaces. The aim of this study was to investigate if human herpes virus DNA could be found in malignant melanomas in sun-sheltered body areas and if these viruses play a role in the development of extracutaneous melanomas.
Forty-one extracutaneous melanomas were dissected and used for further analysis. Quantitative PCR methods were used for detection of the eight human herpes viruses in melanoma samples.
Human herpes virus DNA was absent in 37/41 melanomas, however, cytomegalovirus DNA was detected in two samples, and one sample each exhibited presence of Epstein-Barr virus and Human Herpes virus-6 DNA respectively.
Human herpes virus DNA is rarely detected in primary malignant melanomas in non-sun exposed body surfaces and is not a major factor for the development of extracutaneous melanomas.
紫外线辐射是皮肤恶性黑色素瘤最重要的致病因素。然而，对于阳光照射不到的身体表面的黑色素瘤来说并非如此。本研究的目的是调查在阳光照射不到的身体部位的恶性黑色素瘤中是否能发现人类疱疹病毒DNA，以及这些病毒是否在皮肤外黑色素瘤的发生中起作用。
解剖41例皮肤外黑色素瘤用于进一步分析。采用定量PCR方法检测黑色素瘤样本中的8种人类疱疹病毒。
41例黑色素瘤中有37例未检测到人类疱疹病毒DNA，然而，在两个样本中检测到了巨细胞病毒DNA，另外各有一个样本分别检测到了爱泼斯坦-巴尔病毒和人类疱疹病毒6型DNA。
在非阳光暴露身体表面的原发性恶性黑色素瘤中很少检测到人类疱疹病毒DNA，且不是皮肤外黑色素瘤发生的主要因素。
