原发性黏膜黑色素瘤中未检测到人多瘤病毒、TSPyV、MWPyV、HPyV6、7 和 9 的 DNA。
DNA from human polyomaviruses, TSPyV, MWPyV, HPyV6, 7 and 9 was not detected in primary mucosal melanomas.
机构信息
Department Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK R8:01, SE-171 76 Stockholm, Sweden.
出版信息
Anticancer Res. 2014 Feb;34(2):639-43.
BACKGROUND/AIM: Mucosal melanomas arise in non UV-light exposed areas and causative factors are yet unknown. Human polyomaviruses (HPyVs) are rapidly increasing in numbers and are potentially oncogenic, as has been established for MCPyV in Merkel cell carcinoma, an unusual skin cancer type. The aim of the present study was to investigate the association between TSPyV, MWPyV, HPyV6, 7 and 9 and mucosal melanoma.
MATERIALS AND METHODS
Fifty-five mucosal melanomas, were analyzed by a Luminex assay, for the presence of 10 HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, TSPyV, MWPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV).
RESULTS
In 37 samples the DNA quality was satisfactory for analysis. However, none of the samples analyzed were positive for any of the examined viruses.
CONCLUSION
None of the above-analyzed HPyVs were detected in mucosal melanoma samples, and they are for this reason unlikely to play a major role in the development of this tumor type.
背景/目的：黏膜黑色素瘤发生于非紫外线照射区域，其致病因素尚不清楚。人多瘤病毒（HPyV）的数量正在迅速增加，具有潜在的致癌性，这已在 Merkel 细胞癌（一种罕见的皮肤癌类型）中得到证实，MCPyV 就是 Merkel 细胞癌的致癌病毒之一。本研究旨在探讨 TSPyV、MWPyV、HPyV6、7 和 9 与黏膜黑色素瘤之间的关联。
材料和方法
采用 Luminex 检测法对 55 例黏膜黑色素瘤组织进行了 10 种 HPyV（BKPyV、JCPyV、KIPyV、WUPyV、TSPyV、MWPyV、HPyV6、7 和 9）和两种灵长类病毒（SV40 和 LPyV）的检测。
结果
在 37 个样本中，DNA 质量分析结果令人满意。然而，分析的样本均未检测到任何一种被检测病毒的阳性。
结论
黏膜黑色素瘤组织中未检测到上述分析的 HPyV，因此它们不太可能在这种肿瘤类型的发展中起主要作用。
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