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微生物学检查对下呼吸道感染诊断的贡献

[Contribution of microbiological investigations to the diagnosis of lower respiratory tract infections].

作者信息

Leroy O

机构信息

Service de réanimation médicale et maladies infectieuses, hôpital G.-Chatiliez, 135, rue du Président-Coty, 59208 Tourcoing, France.

出版信息

Med Mal Infect. 2006 Nov-Dec;36(11-12):570-98. doi: 10.1016/j.medmal.2006.07.008. Epub 2006 Nov 13.

DOI:10.1016/j.medmal.2006.07.008
PMID:17095176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7119138/
Abstract

The diagnosis of community-acquired pneumonia is usually based on clinical and radiological criteria. The identification of a causative organism is not required for the diagnosis. Although numerous microbiological techniques are available, their sensitivity and specificity are not high enough to guide first-line antimicrobial therapy. Consequently, this treatment remains most often empiric. If the causative organism is identified, the antimicrobial treatment is adapted. Sputum analysis may be proposed as a diagnostic tool for patients with an acute exacerbation of chronic obstructive pulmonary disease, in specific cases (prior antibiotherapy, hospitalization, failure of the empiric antimicrobial treatment).

摘要

社区获得性肺炎的诊断通常基于临床和影像学标准。诊断时无需确定病原体。尽管有多种微生物学技术可用,但其敏感性和特异性不足以指导一线抗菌治疗。因此,这种治疗通常仍为经验性治疗。如果确定了病原体,则调整抗菌治疗。对于慢性阻塞性肺疾病急性加重的患者,在特定情况下(先前接受过抗生素治疗、住院、经验性抗菌治疗失败),可建议进行痰液分析作为诊断工具。

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Microbial airway colonization is associated with noninvasive ventilation failure in exacerbation of chronic obstructive pulmonary disease.微生物气道定植与慢性阻塞性肺疾病急性加重期无创通气失败相关。
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Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season.流感季节期间旧金山大学医学中心诊所引发急性呼吸道感染的病毒病原体特征分析。
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The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia.住院社区获得性肺炎治疗中联合治疗与单一疗法的争议。
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Comparison between pathogen directed antibiotic treatment and empirical broad spectrum antibiotic treatment in patients with community acquired pneumonia: a prospective randomised study.社区获得性肺炎患者中病原体导向性抗生素治疗与经验性广谱抗生素治疗的比较:一项前瞻性随机研究。
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Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease.社区获得性肺炎和慢性阻塞性肺疾病加重的成人患者中的人偏肺病毒感染
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Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction.通过实时聚合酶链反应改善社区获得性肺炎病因的诊断。
Clin Infect Dis. 2005 Aug 1;41(3):345-51. doi: 10.1086/431588. Epub 2005 Jun 22.
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Evaluation of PCR and nested PCR assays currently used for detection of Coxiella burnetii in Japan.日本目前用于检测伯氏考克斯氏体的聚合酶链反应(PCR)和巢式PCR检测方法的评估
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Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the "gold standard".以聚合酶链反应(PCR)作为“金标准”,对12种商业检测方法以及肺炎支原体特异性免疫球蛋白G(IgG)和免疫球蛋白M(IgM)抗体的补体结合试验进行评估。
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Respiratory syncytial virus infection in elderly and high-risk adults.老年人及高危成年人的呼吸道合胞病毒感染
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