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本文引用的文献

1
Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1.蛋白激酶Npr1对酿酒酵母中Gln3定位的氨特异性调控
J Biol Chem. 2006 Sep 22;281(38):28460-9. doi: 10.1074/jbc.M604171200. Epub 2006 Jul 24.
2
Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.在酿酒酵母中，激活Gln3介导转录的氮信号转导独立于Npr1激酶和Rsp5-Bul1/2泛素连接酶。
J Biol Chem. 2006 Sep 29;281(39):28546-54. doi: 10.1074/jbc.M605551200. Epub 2006 Jul 24.
3
Identification of new Golgi complex specific proteins by direct organelle proteomic analysis.通过直接细胞器蛋白质组学分析鉴定新的高尔基体复合物特异性蛋白质。
Proteomics. 2006 Jun;6(12):3502-8. doi: 10.1002/pmic.200500516.
4
TOR signaling in growth and metabolism.生长与代谢中的TOR信号传导
Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016.
5
Multiple functions of the vacuolar sorting protein Ccz1p in Saccharomyces cerevisiae.酿酒酵母中液泡分选蛋白Ccz1p的多种功能。
Biochem Biophys Res Commun. 2005 Apr 1;329(1):197-204. doi: 10.1016/j.bbrc.2005.01.107.
6
NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.NPR1激酶和RSP5-BUL1/2泛素连接酶调控酿酒酵母中GLN3依赖的转录。
J Biol Chem. 2004 Sep 3;279(36):37512-7. doi: 10.1074/jbc.M407372200. Epub 2004 Jul 9.
7
The N-terminal domain of yeast Bap2 permease is phosphorylated dependently on the Npr1 kinase in response to starvation.酵母Bap2通透酶的N端结构域在饥饿响应中依赖Npr1激酶进行磷酸化。
FEMS Microbiol Lett. 2004 Jan 30;230(2):227-34. doi: 10.1016/S0378-1097(03)00918-2.
8
TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.TOR复合物1包含一个新组分Tco89p（YPL180w），并与Ssd1p协同作用以维持酿酒酵母中的细胞完整性。
J Biol Chem. 2004 Apr 9;279(15):14752-62. doi: 10.1074/jbc.M313062200. Epub 2004 Jan 21.
9
FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus.FKBP12-雷帕霉素相关蛋白或雷帕霉素哺乳动物靶蛋白（FRAP/mTOR）在内质网和高尔基体中的定位。
J Biol Chem. 2004 Jan 2;279(1):772-8. doi: 10.1074/jbc.M305912200. Epub 2003 Oct 24.
10
LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway.LST8作为TOR通路的一个组成部分，对氨基酸生物合成起负调控作用。
J Cell Biol. 2003 Apr 28;161(2):333-47. doi: 10.1083/jcb.200210141.

Pmr1是一种高尔基体Ca2+/Mn2+ -ATP酶，是酵母中雷帕霉素靶蛋白（TOR）信号通路的调节因子。

Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast.

作者信息

Devasahayam Gina, Ritz Danilo, Helliwell Stephen B, Burke Daniel J, Sturgill Thomas W

机构信息

Departments of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

出版信息

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17840-5. doi: 10.1073/pnas.0604303103. Epub 2006 Nov 9.

DOI:10.1073/pnas.0604303103
PMID:17095607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1693834/
Abstract

The rapamycin.FKBP12 complex inhibits target of rapamycin (TOR) kinase in TORC1. We screened the yeast nonessential gene deletion collection to identify mutants that conferred rapamycin resistance, and we identified PMR1, encoding the Golgi Ca2+/Mn2+ -ATPase. Deleting PMR1 in two genetic backgrounds confers rapamycin resistance. Epistasis analyses show that Pmr1 functions upstream from Npr1 and Gln-3 in opposition to Lst8, a regulator of TOR. Npr1 kinase is largely cytoplasmic, and a portion localizes to the Golgi where amino acid permeases are modified and sorted. Nuclear translocation of Gln-3 and Gln-3 reporter activity in pmr1 cells are impaired, but expression of functional Gap1 in the plasma membrane of a pmr1 strain in response to nitrogen limitation is enhanced. These two phenotypes suggest up-regulation of Npr1 function in the absence of Pmr1. Together, our results establish that Pmr1-dependent Ca2+ and/or Mn2+ ion homeostasis is necessary for TOR signaling.

摘要

雷帕霉素与FKBP12复合物可抑制TORC1中的雷帕霉素靶蛋白（TOR）激酶。我们筛选了酵母非必需基因缺失文库，以鉴定赋予雷帕霉素抗性的突变体，并鉴定出了编码高尔基体Ca2+/Mn2+ -ATP酶的PMR1。在两种遗传背景下删除PMR1均可赋予雷帕霉素抗性。上位性分析表明，Pmr1在与TOR的调节因子Lst8相反的方向上，在Npr1和Gln-3的上游发挥作用。Npr1激酶主要位于细胞质中，有一部分定位于高尔基体，在高尔基体中氨基酸通透酶会被修饰和分选。pmr1细胞中Gln-3的核转位及Gln-3报告基因活性受损，但在氮限制条件下，pmr1菌株质膜中功能性Gap1的表达会增强。这两种表型表明在缺乏Pmr1的情况下Npr1功能上调。总之，我们的结果表明，Pmr1依赖的Ca2+和/或Mn2+离子稳态对于TOR信号传导是必需的。