Hall Andrew M, Unwin Robert J
Centre for Nephrology and Department of Physiology (Epithelial Transport and Cell Biology Group), Royal Free and University College Medical School, London, UK.
Nephron Physiol. 2007;105(1):p1-10. doi: 10.1159/000096860. Epub 2006 Nov 8.
Mitochondria are intracellular organelles with a variety of vital functions, including the provision of energy in the form of adenosine 5'-triphosphate. Increasingly, we are becoming more aware of the importance of mitochondrial dysfunction in a number of common medical conditions. In this review and overview, we focus on the growing evidence that mitochondrial dysfunction is involved in either the etiology or underlying pathophysiology of a broad spectrum of renal diseases, including acute renal injury due to ischemia-reperfusion injury, renal Fanconi syndrome, and glomerular disorders such as focal segmental glomerulosclerosis. In addition, mitochondrial dysfunction may also contribute to the growing burden of chronic kidney disease seen in our aging population, which is still largely unexplained. Unfortunately, at present, our ability to diagnose and treat renal disorders related to mitochondrial dysfunction is limited, and further work in this field is needed.
线粒体是具有多种重要功能的细胞内细胞器，包括以三磷酸腺苷的形式提供能量。我们越来越意识到线粒体功能障碍在许多常见医学病症中的重要性。在这篇综述和概述中，我们关注越来越多的证据表明，线粒体功能障碍参与了广泛的肾脏疾病的病因或潜在病理生理学过程，包括缺血再灌注损伤所致的急性肾损伤、肾范科尼综合征以及局灶节段性肾小球硬化等肾小球疾病。此外，线粒体功能障碍也可能导致在老年人群中日益增加的慢性肾脏病负担，而这在很大程度上仍无法解释。不幸的是，目前我们诊断和治疗与线粒体功能障碍相关的肾脏疾病的能力有限，该领域需要进一步开展研究。
