Pache Mona, Meyer Peter
University Eye Clinic Freiburg, Freiburg, Germany.
Ophthalmologica. 2006;220(6):393-6. doi: 10.1159/000095867.
This work focuses on the possible remodeling of the intraorbital portion of the optic nerve and its meningeal sheaths in glaucoma. The bulbar segments of the orbital optic nerve portion from 25 donors with glaucoma (M:F = 8:17; mean age +/- SD 85 +/- 11 years) and 25 controls (M:F = 14:11; mean age +/- SD 81 +/- 8 years) were formalin fixed, paraffin embedded and sectioned in series. Sections were stained with PAS, Masson trichrome and CD68, and examined for the following parameters: (1) diameter of the optic nerve; (2) thickness of the pia mater; (3) distance between dura mater and pia mater; (4) occurrence and amount of meningothelial cell nests in the subarachnoid space, and (5) presence and number of corpora arenacea. The mean diameter of the optic nerve was decreased in the glaucoma group when compared to the controls (2.9 +/- 0.5 vs. 3.3 +/- 0.5 mm; p < 0.01). The thickness of the pia mater was increased in the glaucoma group (0.1 +/- 0.04 vs. 0.09 +/- 0.03 mm, p < 0.05). Presence and number of corpora arenacea did not differ between the groups. Occurrence and amount of meningo- thelial cell nests in the subarachnoid space were however significantly increased in glaucoma (p < 0.02). Whether this observation is glaucoma specific deserves further investigation.
这项研究聚焦于青光眼患者眶内段视神经及其脑膜鞘可能发生的重塑。选取25例青光眼供体（男:女 = 8:17；平均年龄±标准差85±11岁）和25例对照者（男:女 = 14:11；平均年龄±标准差81±8岁）的眶部视神经球部节段，用福尔马林固定、石蜡包埋并进行连续切片。切片用PAS、Masson三色染色法和CD68染色，检查以下参数：（1）视神经直径；（2）软脑膜厚度；（3）硬脑膜与软脑膜之间的距离；（4）蛛网膜下腔内脑膜上皮细胞巢的出现情况及数量；（5）脑砂的存在情况及数量。与对照组相比，青光眼组视神经的平均直径减小（2.9±0.5 vs. 3.3±0.5 mm；p < 0.01）。青光眼组软脑膜厚度增加（0.1±0.04 vs. 0.09±0.03 mm，p < 0.05）。两组间脑砂的存在情况及数量无差异。然而，青光眼患者蛛网膜下腔内脑膜上皮细胞巢的出现情况及数量显著增加（p < 0.02）。这一观察结果是否具有青光眼特异性值得进一步研究。
