Dian D, Schwenn K, Mylonas I, Janni W, Friese K, Jaenicke F
University Hospital Munich, Munich, Germany.
J Cancer Res Clin Oncol. 2007 Apr;133(4):247-52. doi: 10.1007/s00432-006-0163-z. Epub 2006 Nov 10.
Besides the quality of the aesthetic results, the quality of life after surgery is one of the most important criteria when reviewing different operation methods, especially in oncologic diseases. This study was performed to evaluate the difference in the health-related quality of life following breast conserving surgery and autologous breast reconstruction after mastectomy.
Hundred and forty-four breast cancer patients were included in this study. Sixty seven patients underwent breast conserving surgery followed by radiotherapy. In 77 patients a mastectomy was performed with immediate or late reconstruction. To evaluate the health-related quality of life we used the SF-36 self-administered questionnaire.
A significant difference was found in quality of life in the subscale "physical functioning" showing better results in the breast reconstruction group (P = 0.01). No significant difference was found in the other subscales, but there was a tendency to a better "emotional role" among the breast reconstruction patients.
Our study demonstrated that autologous tissue breast reconstruction in breast cancer patients did not affect adversely the health-related quality of life compared to breast conserving therapy when the quality of life is assessed by the standardized questionnaire SF-36. In particular, the physical function is not reported to be significantly influenced negatively by the more extensive surgical therapy.
在评估不同手术方法时，除美学效果质量外，术后生活质量是最重要的标准之一，尤其是在肿瘤疾病中。本研究旨在评估保乳手术与乳房切除术后自体乳房重建术后健康相关生活质量的差异。
本研究纳入了144例乳腺癌患者。67例患者接受保乳手术并随后进行放疗。77例患者接受了乳房切除术并立即或延迟进行重建。为评估健康相关生活质量，我们使用了SF-36自填式问卷。
在“身体功能”子量表中发现生活质量存在显著差异，乳房重建组结果更好（P = 0.01）。在其他子量表中未发现显著差异，但乳房重建患者中“情感角色”有更好的趋势。
我们的研究表明，当通过标准化问卷SF-36评估生活质量时，与保乳治疗相比，乳腺癌患者的自体组织乳房重建对健康相关生活质量没有不利影响。特别是，更广泛的手术治疗未被报告对身体功能有显著负面影响。
