Nwaobasi Eberechi, Oleske James M
Department of Pediatrics, University of Medicine and Dentistry of New Jersey, University Hospital, Newark, New Jersey, USA.
AIDS Read. 2006 Oct;16(10):537-40, 544-6,549-50, 552-4.
The addition of highly active antiretroviral therapy to the complex regimens used to treat HIV-infected persons has extended the lives of millions. Despite the proven benefits of antiretroviral therapy, adverse events can occur with its use. These reactions can be separated into several distinct categories: mitochondrial dysfunction, metabolic abnormalities, hematologic complications, and allergic reactions. Drug-associated complications can be particularly challenging to treat when they occur in pediatric HIV patients. Care providers who manage HIV-infected children have to be cognizant of these complications when patients present with symptoms because some can mimic manifestations of HIV infection itself. These adverse reactions are neither uncommon nor unexpected, and discontinuation of the inciting agent is not always mandated. But every effort must be made to address them when they do occur so that adequate treatment is given in a timely manner.
在用于治疗HIV感染者的复杂治疗方案中加入高效抗逆转录病毒疗法，已延长了数百万人的生命。尽管抗逆转录病毒疗法已被证明有益，但使用过程中仍可能出现不良事件。这些反应可分为几个不同类别：线粒体功能障碍、代谢异常、血液学并发症和过敏反应。药物相关并发症在儿科HIV患者中出现时，治疗可能会特别具有挑战性。当HIV感染儿童出现症状时，负责管理这些儿童的医护人员必须认识到这些并发症，因为有些并发症可能会模仿HIV感染本身的表现。这些不良反应既不罕见也非意料之外，并不总是必须停用引发药物。但当不良反应确实发生时，必须尽一切努力加以应对，以便及时给予充分治疗。
