Miyazawa Reiko, Tomomasa Takeshi, Kaneko Hiroaki, Morikawa Akihiro
Department of Pediatrics and Developmental Medicine, Gunma University Graduate School, Maebashi, Gunma, Japan.
J Paediatr Child Health. 2006 Dec;42(12):808-12. doi: 10.1111/j.1440-1754.2006.00982.x.
We investigated the effects of milk-based formulas thickened with two different concentrations of locust bean gum on gastric emptying in infants with recurrent regurgitation episodes.
Thirty-nine infants with three or more episodes of regurgitation per day but no complications who were fed mainly with infant formula were studied. We first compared gastric emptying in infants fed with formulas thickened with two different concentrations of locust bean gum (HL-350, 0.35 g/100 mL; HL-450, 0.45 g/100 mL) or a regular formula (HL-00). To evaluate gastric emptying, we measured antral cross-sectional areas ultrasonographically at various time points after feeding. Next, to investigate the clinical effect of thickened formulas on regurgitation episodes, 27 infants with episodes were assigned randomly to receive HL-350 and HL-00 or HL-450 and HL-00 for 1 week each.
Antral cross-sectional areas at 60, 90, 120 and 150 min with HL-450, and at 60 min with HL-350, were greater than with HL-00. The median gastric emptying rate at 120 min with HL-450 (52.8%) was lower than with HL-00 (97.9%; P = 0.0019), while HL-350 (80.3%) and HL-00 did not differ significantly. The mean number of regurgitation episodes was significantly smaller when infants were fed with either HL-350 or HL-450 than with HL-00.
HL-450, a thickened formula with typical commercially available concentrations of locust bean gum, slowed gastric emptying in infants with gastroesophageal reflux.
我们研究了用两种不同浓度刺槐豆胶增稠的乳基配方奶粉对反复出现反流发作的婴儿胃排空的影响。
对39名主要以婴儿配方奶粉喂养、每天有三次或更多次反流发作但无并发症的婴儿进行了研究。我们首先比较了用两种不同浓度刺槐豆胶（HL - 350，0.35 g/100 mL；HL - 450，0.45 g/100 mL）增稠的配方奶粉或常规配方奶粉（HL - 00）喂养的婴儿的胃排空情况。为了评估胃排空，我们在喂食后的不同时间点通过超声测量胃窦横截面积。接下来，为了研究增稠配方奶粉对反流发作的临床效果，将27名有反流发作的婴儿随机分为两组，分别接受HL - 350和HL - 00或HL - 450和HL - 00，每组各1周。
HL - 450在60、90、120和150分钟时以及HL - 350在60分钟时的胃窦横截面积大于HL - 00。HL - 450在120分钟时的胃排空率中位数（52.8%）低于HL - 00（97.9%；P = 0.0019），而HL - 350（80.3%）和HL - 00之间无显著差异。当婴儿喂食HL - 350或HL - 450时，反流发作的平均次数明显少于喂食HL - 00时。
HL - 450是一种具有典型市售浓度刺槐豆胶的增稠配方奶粉，可减缓胃食管反流婴儿的胃排空。
