刺槐豆胶浓度降低增稠配方对胃食管反流的影响

Effect of formula thickened with reduced concentration of locust bean gum on gastroesophageal reflux.

作者信息

Miyazawa R, Tomomasa T, Kaneko H, Arakawa H, Morikawa A

机构信息

Department of Pediatrics and Developmental Medicine, Gunma University Graduate School, Maebashi, Japan.

出版信息

Acta Paediatr. 2007 Jun;96(6):910-4. doi: 10.1111/j.1651-2227.2007.00279.x.

DOI:10.1111/j.1651-2227.2007.00279.x

PMID:17537023

Abstract

AIM

Previous studies showed that HL-350, a formula thickened with a reduced concentration of locust bean gum, decreased frequent regurgitation in 4-month old infants with reflux. In this study, we investigated the effect of HL-350 in younger infants.

METHODS

We studied 20 infants less than 2 months old who had three or more episodes of regurgitation or vomiting per day. Ten infants (group A) were fed with HL-350 for the first week, and with control milk, HL-00, for the following week. The other 10 infants (group B) were fed in reverse order. Mothers recorded number of regurgitation episodes, feeding volume and time and number of bowel movements. To evaluate gastric emptying we measured antral cross sectional areas ultrasonographically at various time points after feeding.

RESULTS

The median number of regurgitation episodes decreased significantly with feeding of HL-350 (2.3/day) compared to feeding with control milk (5.2/day) (p = 0.00048). No significant difference was evident in feeding volume and time, body weight gain, or gastric emptying rate between HL-350 and control milk.

CONCLUSION

HL-350 decreased the number of regurgitation episodes without affecting gastric emptying delay in very young infants with recurrent vomiting.

摘要

目的

先前的研究表明，HL - 350（一种用降低浓度的刺槐豆胶增稠的配方奶）可减少4个月大反流婴儿的频繁反流。在本研究中，我们调查了HL - 350对更小婴儿的影响。

方法

我们研究了20名2个月以下、每天有3次或更多次反流或呕吐发作的婴儿。10名婴儿（A组）第一周喂食HL - 350，接下来一周喂食对照奶HL - 00。另外10名婴儿（B组）按相反顺序喂食。母亲们记录反流发作次数、喂食量和时间以及排便次数。为评估胃排空情况，我们在喂食后的不同时间点通过超声测量胃窦横截面积。