Engels Eric A, Mbulaiteye Sam M, Othieno Emmanuel, Gomez Mario, Mathew Susan, Cesarman Ethel, Knowles Daniel M, Chadburn Amy
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA.
Hum Pathol. 2007 Feb;38(2):308-14. doi: 10.1016/j.humpath.2006.08.009. Epub 2006 Nov 13.
Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lymphomas (NHLs) and reactive lymphadenopathy in this region. One hundred forty-four cases (80 NHLs, 64 reactive lymph nodes) from the major pathology laboratory in Uganda were reviewed. One NHL was KSHV-positive, as indicated by staining for the viral latent nuclear antigen. This NHL was a diffuse large B-cell lymphoma in a 5-year-old boy. The tumor was also Epstein-Barr virus-positive. In addition, 2 reactive lymph nodes, both classified histologically as follicular involution, stained KSHV latent nuclear antigen-positive and thus most likely represent multicentric Castleman disease. In all 3 KSHV-positive cases, a minority of cells expressed KSHV viral interleukin 6, a biologically active cytokine homolog. In conclusion, we show that KSHV is rarely associated with lymphoproliferative disorders in sub-Saharan Africa. We describe the first case of a KSHV-positive NHL from this region; this case is also the first reported pediatric lymphoma associated with KSHV infection.
卡波西肉瘤相关疱疹病毒（KSHV）可引发卡波西肉瘤，还与原发性渗出性淋巴瘤（弥漫性大B细胞淋巴瘤的一个亚型）及多中心Castleman病有关。由于KSHV感染在撒哈拉以南非洲地区呈地方性流行，我们试图在此地区识别KSHV阳性的非霍奇金淋巴瘤（NHL）病例及反应性淋巴结病。我们回顾了来自乌干达主要病理实验室的144例病例（80例NHL，64例反应性淋巴结）。经病毒潜伏核抗原染色显示，有1例NHL为KSHV阳性。该NHL是一名5岁男孩的弥漫性大B细胞淋巴瘤。该肿瘤同时也是爱泼斯坦-巴尔病毒阳性。此外，2例组织学分类为滤泡退化的反应性淋巴结KSHV潜伏核抗原染色呈阳性，因此很可能代表多中心Castleman病。在所有3例KSHV阳性病例中，少数细胞表达KSHV病毒白细胞介素6，这是一种具有生物活性的细胞因子同源物。总之，我们发现KSHV在撒哈拉以南非洲地区很少与淋巴增殖性疾病相关。我们描述了该地区首例KSHV阳性的NHL病例；该病例也是首例报道的与KSHV感染相关的儿童淋巴瘤。
